Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression.

May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist likely by competing with the negative FLII regulator for MYD88-binding.