LRRC25 Antibodies

AND LRRC25 ELISA kits, LRRC25 Proteins

Many biological assays use antibodies to detect LRRC25, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRRC25 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRRC25 antibodies...

We validate the specificity of these antibodies to LRRC25 by testing them on tissues known to express LRRC25 positively and negatively. Browse below to find the LRRC25 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRRC25 Infographic by Boster Bio

All LRRC25 Products

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Product

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Specificity

Applications

Price

Anti-LRRC25 Mouse Monoclonal Antibody [Clone ID: OTI1D9]

Human

Flow Cytometry, IF, IHC, WB

$523
Cat # M15963
100 µl

LRRC25 (NM_145256) Human Over-expression Lysate

Human

$628
Cat # LS126364
100 µg

LRRC25 Overview

Facts about Leucine-rich repeat-containing protein 25.

LRRC25 3D structure. Source: alphafold

Leucine-rich repeat-containing protein 25 (LRRC25)

Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15- associated DDX58 to encourage interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164).

Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. .

Gene Information

Human
Gene Name:	LRRC25
Uniprot:	Q8N386
Entrez:	126364

Family

Belongs to:

No superfamily

Alternative Names

leucine rich repeat containing 25; leucine-rich repeat-containing protein 25; MAPAFLJ38116; monocyte and plasmacytoid activated molecule; Monocyte and plasmacytoid-activated protein

Molecular Weight

Mass (kDA):
33.179 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (18391137..18397645, complement)

Tissue Specificity

Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cytoplasm.

Diseases

Malaria
Malaria, Falciparum

Interacting Proteins

Pathways

Antigen Processing And Presentation

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRRC25

References

PMID: 12384430 by Rissoan M.-C., et al. Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells.

PMID: 29044191 by Feng Y., et al. LRRC25 functions as an inhibitor of NF-kappaB signaling pathway by promoting p65/RelA for autophagic degradation.