LRP8 Antibodies

Low-density lipoprotein receptor-related protein 8 (LRP8)

LRP8 participates in distributing the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to modulate DAB1 tyrosine phosphorylation and microtubule function in neurons.

LRP8 has greater affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development.

Gene Information

Human
Gene Name:	LRP8
Uniprot:	Q14114
Entrez:	7804

Family

Belongs to:
LDLR family

Alternative Names

ApoER2; APOER2HSZ75190; Apolipoprotein E R2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8; Lr8b; LRP8; LRP-8; MCI1

Molecular Weight

Mass (kDA):
105.634 kDA

Genomic Context

Human
Location:	1p32.3
Sequence:	1; NC_000001.11 (53242364..53328070, complement)

Tissue Specificity

Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Secreted. Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.

Diseases

• Infarction
• Myocardial Infarction
• Alzheimer's Disease
• Coronary Artery Disease
• Atherosclerosis
• Thrombosis
• Malignant Neoplasms
• Nervousness
• Schizophrenia
• Tissue Adhesions
• Neoplasms
• Hemorrhage

• Lissencephaly
• Thrombus
• Parkinson Disease
• Cardiovascular Diseases
• Cell Invasion
• Cholangiocarcinoma
• Neoplasm Metastasis

Interacting Proteins

• APC
• APOE
• KDR
• Reln

Pathways

• Transport
• Platelet Activation
• Platelet Aggregation
• Endocytosis
• Brain Development
• Cholesterol Efflux
• Hemostasis
• Lipid Transport
• Ovulation
• Cholesterol Homeostasis
• Secretion
• Response To Lipopolysaccharide
• Cell Migration

• Osteoblast Differentiation
• Lung Development
• Neurogenesis
• Regulation Of Gene Expression
• Sterol Homeostasis
• Mrna Splicing
• Mrna Transcription

PTMs

• Phosphorylation

• Cleavage

Research Areas

• Alzheimers Research
• Lipid and Metabolism
• Neurodegeneration
• Neuronal Cell Markers
• Neuroscience

• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP8

Boster Bio - Best Uses Of The LRP8 Marker

If you're working with the LRP8 marker you've probably been wondering what the most effective uses for the molecule are. Boster Bio's PICOKINE (tm) ELISA kit is the best choice. Boster Bio's antibodies can be used to be used for various research purposes. Boster Bio's PICOBAND (tm) ELISA kits can also be used if you are working with this marker.

Boster Bio's research primary and secondary antibodies

Boster Bio Lab offers an array of high-quality ELISA kits, as well as antibodies. There are over 16,000 products. Boster's products are rigorously validated and are available in ELISA, WB, and FC formats. Boster provides human and mouse samples and guarantees that each product will perform as stated. The LRP8 marker which is both highly specific and not-specific , can be used to identify the cell's cytoplasmic region.

To create this antibody, the cell lines were starved for 12 hours. The cells were cleaned, trypsinized, and resuspended with 70 percent ethanol or PBS. The cells were then identified using a Beckman FC500 flowcytometer. The data were then analyzed using ModFit software after the cells were detected.

A serum containing 5642s (CST, USA) was used to create the primary antibody in this experiment. It was then dilute to a 1:100, or 1:200 ratio and incubated for a night at 4°C. Secondary antibodies were added after the primary antibody and streptavidin-horseradish peroxidase, followed by counterstaining with hematoxylin.

The LRP8 molecules is a great research area for the creation of new antibodies to fight cancer and other medical research. These antibodies are available in a variety of formats to satisfy the various research needs. Boster Bio has a range of reagents including primary and secondary antibodies based on the LRP8 marker. The LRP8 marker is a popular anti-cancer antibody's target including human cancer cells.

Boster Bio's PICOKINE(tm) ELISA kits

A breakthrough in ELISA technology, Picokine(tm) enables high sensitivity ELISA detection at the picogram level. These ELISA kits have been thoroughly tested for use on a wide range of samples. They also have a high degree of specificity with sensitivity at the picogram level and high specificity. Boster Bio has more than 20 years of experience, and is trusted by more than 10,000 scientists from around the world. Scientists can accelerate their research with the Picokine(tm) which is an ELISA kit that uses the LRP8 marker. It contains enough reagents to conduct the testing of 96 samples.

Boster Bio's PICOKINETM ELISA kits are used to detect the LRP8 marker. They reduce binding that is not specific and increase the effectiveness of binding of the capture antibody. They provide single-digit picogram level sensitivities. They are tested at 37°C for at least one week to guarantee accurate results. Microplates with 96 wells are included in each kit Each reagent is comprised of enough quantities to conduct multiple tests.

Boster Bio's PICOBAND (tm) ELISA kit

The LRP8 marker is a very relevant cancer biomarker , and Boster Bio's PICOBAND ELISA kits allow for the sensitive detection of the protein. Their innovative ELISA kits have picogram sensitivity and have been validated for use in a wide variety of sample types. Boster Bio's PICOBAND(tm) technology is based on knowledge gained from the design of immunogens and is supported by the technical support provided by their distributor, Sanbio.