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LRP5 Antibodies
AND LRP5 ELISA kits, LRP5 Proteins
Many biological assays use antibodies to detect LRP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRP5 antibodies...
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LRP5 Overview
Facts about Low-density lipoprotein receptor-related protein 5.
Low-density lipoprotein receptor-related protein 5 (LRP5)
Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed:11336703, PubMed:11448771, PubMed:15778503, PubMed:11719191, PubMed:15908424, PubMed:16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11336703, PubMed:11719191).
In particular, may play an essential role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11719191).
Gene Information
| Human | |
|---|---|
| Gene Name: | LRP5 |
| Uniprot: | O75197 |
| Entrez: | 4041 |
Family
| Belongs to: |
|---|
| LDLR family |
Alternative Names
BMND1; BMND1OPTA1; EVR1; EVR4; HBM; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 7; low-density lipoprotein receptor-related protein 5; LR3VBCH2; LRP5; LRP-5; LRP7; LRP7exudative vitreoretinopathy 1; OPPG; OPS; OPTA1; osteoporosis pseudoglioma syndrome; VBCH2
Molecular Weight
Mass (kDA):
179.145 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.2 |
| Sequence: | 11; NC_000011.10 (68298866..68449275) |
Tissue Specificity
Widely expressed, with the highest level of expression in the liver and in aorta.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Chaperoned to the plasma membrane by MESD.
Diseases
- Osteoporosis
- Fracture
- Malignant Neoplasms
- Neoplasms
- Bone Diseases
- Osteopenia
- Osteoporosis With Pseudoglioma
- Blind Vision
- Retinal Diseases
- Diabetes Mellitus
- Norrie Disease
- Cell Transformation, Neoplastic
Interacting Proteins
- APCDD1
- CAPRIN2
- SOST
Pathways
- Pathogenesis
- Osteoblast Differentiation
- Cell Proliferation
- Bone Resorption
- Bone Remodeling
- Regeneration
- Localization
- Secretion
- Angiogenesis
- Transport
- Osteoblast Proliferation
- Bone Development
- Endocytosis
PTMs
- Phosphorylation
- Cleavage
- Ubiquitination
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP5
bosterbio.com/bosterbio-gene-info-cards/LRP5
References
PMID: 9790987 by Dong Y., et al. Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity.
PMID: 9714764 by Hey P.J., et al. Cloning of a novel member of the low-density lipoprotein receptor family.