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- Table of Contents
Facts about Prolow-density lipoprotein receptor-related protein 1.
Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and triggered LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.
Human | |
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Gene Name: | LRP1 |
Uniprot: | Q07954 |
Entrez: | 4035 |
Belongs to: |
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LDLR family |
A2MR; Alpha-2-Macroglobulin Receptor; APOER; Apolipoprotein E receptor; APR; CD91 antigen; CD91; EC 1.1.1.94; EC 3.4.21.9; IGFBP3R; low density lipoprotein receptor-related protein 1; LRP; LRP-1; LRP1A; prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
Mass (kDA):
504.606 kDA
Human | |
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Location: | 12q13.3 |
Sequence: | 12; NC_000012.12 (57128401..57213377) |
Most abundant in liver, brain and lung.
[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm. Nucleus. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.; Postsynaptic Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center. Localizes to
PMID: 3266596 by Herz J., et al. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.
PMID: 7534747 by Van Leuven F., et al. Structure of the gene (LRP1) coding for the human alpha 2- macroglobulin receptor lipoprotein receptor-related protein.