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LRP2 Antibodies
AND LRP2 ELISA kits, LRP2 Proteins
Many biological assays use antibodies to detect LRP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRP2 antibodies...
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LRP2 Overview
Facts about Low-density lipoprotein receptor-related protein 2.
Low-density lipoprotein receptor-related protein 2 (LRP2)
In the gut, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis in the choroid plexus epithelium (By similarity).
Endocytosis of leptin in neuronal cells is needed for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | LRP2 |
| Uniprot: | P98164 |
| Entrez: | 4036 |
Family
| Belongs to: |
|---|
| LDLR family |
Alternative Names
calcium sensor protein; DBS; DBSlow-density lipoprotein receptor-related protein 2; EC 1.1.2.3; EC 3.4.21.9; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; low density lipoprotein receptor-related protein 2; LRP2; LRP-2; Megalin
Molecular Weight
Mass (kDA):
521.958 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (169127109..169362597, complement) |
Tissue Specificity
Expressed in first and third trimester cytotrophoblasts in the placenta (at protein level) (PubMed:27798286). Absorptive epithelia, including renal proximal tubules.
Subcellular Localizations
Apical cell membrane; Single-pass type I membrane protein. Endosome lumen. Membrane, coated pit. Cell projection, dendrite. Cell projection, axon. Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form.
Diseases
- Proteinuria Of Undiagnosed Cause
- Alzheimer's Disease
- Nervousness
- Nephritis
- Sensorineural Hearing Loss (disorder)
- Myopia
- Autoimmune Reaction
- Kidney Diseases
- Donnai Barrow Syndrome
- Intraocular Pressure Disorder
- Glomerulonephritis
- Nerve Degeneration
Pathways
- Transport
- Endocytosis
- Excretion
- Localization
- Forebrain Development
- Proteolysis
- Regeneration
- Neurogenesis
- Transcytosis
- Receptor-mediated Endocytosis
- Neuroprotection
- Secretion
- Brain Development
PTMs
- Cleavage
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP2
bosterbio.com/bosterbio-gene-info-cards/LRP2
References
PMID: 8706697 by Hjaelm G., et al. Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties.
PMID: 7959795 by Korenberg J.R., et al. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1).