LPAR2 Antibodies

AND LPAR2 ELISA kits, LPAR2 Proteins

Many biological assays use antibodies to detect LPAR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LPAR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LPAR2 antibodies...

We validate the specificity of these antibodies to LPAR2 by testing them on tissues known to express LPAR2 positively and negatively. Browse below to find the LPAR2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LPAR2 Infographic by Boster Bio

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Anti-EDG-4 (L310) LPAR2 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A05435-1
100ul

LPAR2 Overview

Facts about Lysophosphatidic acid receptor 2.

LPAR2 3D structure. Source: alphafold

Lysophosphatidic acid receptor 2 (LPAR2)

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.

Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a way that's independent of RALA activation.

Gene Information

Human
Gene Name:	LPAR2
Uniprot:	Q9HBW0
Entrez:	9170

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

EDG4; EDG-4; EDG4FLJ93869; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor4,LPA receptor EDG4; G protein-coupled receptor; LPA2; LPA-2; LPA2LPA receptor 2; LPAR2; lysophosphatidic acid receptor 2; lysophosphatidic acid receptor EDG4; Lysophosphatidic acid receptor Edg-4

Molecular Weight

Mass (kDA):
39.084 kDA

Genomic Context


Human

Location:	19p13.11
Sequence:	19; NC_000019.10 (19623655..19628395, complement)

Tissue Specificity

Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.

Subcellular Localizations

Cell surface. Cell membrane; Multi-pass membrane protein. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.

Diseases

Neoplasms
Malignant Neoplasms
Adenoma
Neoplasm Metastasis
Right Ventricular Hypertrophy
Neoplasm Invasiveness
Degenerative Polyarthritis
Inflammatory Response
Carcinoma
Colorectal Cancer
Malignant Neoplasm Of Pancreas
Pulmonary Hypertension

Rheumatoid Arthritis
Anoxia
Pathologic Vasoconstriction
Cell Invasion
Neuroblastoma
Cell Transformation, Neoplastic
Liver Carcinoma

Interacting Proteins

CFTR
SLC9A3R2

Pathways

Cell Proliferation
Vasodilation
Cell Migration
Localization
Inflammatory Response
Autocrine Signaling
Sensitization
Reverse Transcription
Embryo Implantation
Cell Motility

Blastocyst Development
Vasoconstriction
Pathogenesis
Secretion

PTMs

Glycoprotein

Lipoprotein

Palmitate

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LPAR2

References

PMID: 9525886 by An S., et al. Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid.

PMID: 10922489 by Bandoh K., et al. Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.