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Lysyl oxidase homolog 2 Antibodies
AND LOXL2 ELISA kits, Lysyl oxidase homolog 2 Proteins
Many biological assays use antibodies to detect Lysyl oxidase homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lysyl oxidase homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lysyl oxidase homolog 2 antibodies...
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LOXL2 Infographic by Boster Bio
All LOXL2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1391
96 wells/kit, with removable strips.
Cat # EK1391
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M02539
100 μl
Cat # M02539
100 μl
Human, Mouse, Rat
IHC
$523
Cat # M02539-1
100 µl
Cat # M02539-1
100 µl
LOXL2 Overview
Facts about Lysyl oxidase homolog 2.
Lysyl oxidase homolog 2 (LOXL2)
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137). Acts as a transcription corepressor and especially mediates deamination of trimethylated'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137).
Shows no action against histone H3 when it is trimethylated on'Lys-9' (H3K9me3) or'Lys-27' (H3K27me3) or when'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397).
Gene Information
| Human | |
|---|---|
| Gene Name: | LOXL2 |
| Uniprot: | Q9Y4K0 |
| Entrez: | 4017 |
Family
| Belongs to: |
|---|
| lysyl oxidase family |
Alternative Names
EC 1.4.3; EC 1.4.3.-; LOL2; LOR2; LOXL2; Lysyl Oxidase Homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14; WS9-14
Molecular Weight
Mass (kDA):
86.725 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (23296897..23404120, complement) |
Tissue Specificity
Expressed in many tissues (PubMed:10212285). Highest expression in reproductive tissues, placenta, uterus and prostate (PubMed:10212285). In esophageal epithelium, expressed in the basal, prickle and granular cell layers (PubMed:22204712). Up- regulated in a number of cancers cells and tissues.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus. Chromosome. Endoplasmic reticulum. Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618).
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Cell Invasion
- Malignant Neoplasm Of Breast
- Hypoxia
- Mammary Neoplasms
- Malignant Squamous Cell Neoplasm
- Tumor Progression
- Adenocarcinoma
- Neoplasm Invasiveness
Interacting Proteins
- MARCKSL1
Pathways
- Localization
- Cell Adhesion
- Cell Migration
- Cell Motility
- Senescence
- Pathogenesis
- Cellular Senescence
- Cell Proliferation
- Epithelial To Mesenchymal Transition
- Angiogenesis
- Osteoblast Differentiation
- Nuclear Export
- Reverse Transcription
PTMs
- Methylation
- Phosphorylation
- Hydroxylation
- Deamination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LOXL2
bosterbio.com/bosterbio-gene-info-cards/LOXL2
References
PMID: 9079631 by Saito H., et al. Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.
PMID: 10212285 by Jourdan-Le Saux C., et al. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.