LMTK3 Antibodies

Serine/threonine-protein kinase LMTK3 (LMTK3)

Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly using a PKC-AKT-FOXO3 pathway in which it reduces the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 into the ESR1 promoter and raising ESR1 transcription (PubMed:21602804).

Involved in endocytic trafficking of N-methyl- D-aspartate receptors (NMDAR) in neurons (By similarity). .

Gene Information

Human
Gene Name:	LMTK3
Uniprot:	Q96Q04
Entrez:	114783

Family

Belongs to:
protein kinase superfamily

Alternative Names

AATYK3; EC 2.7.11.1; lemur tyrosine kinase 3KIAA1883TYKLM3LMR3; serine/threonine-protein kinase LMTK3

Molecular Weight

Mass (kDA):
153.661 kDA

Genomic Context

Human
Location:	19q13.33
Sequence:	19; NC_000019.10 (48485271..48513926, complement)

Subcellular Localizations

Membrane; Single-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Golgi apparatus membrane. Punctate pattern in cell projections.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Neoplasms
• Mammary Neoplasms
• Leukemia
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• ESR1

PTMs

• Phosphorylation

Research Areas

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LMTK3

What Are the Best Uses of the LMTK3 Marker?

What are the Best Uses of The LMTK3Marker This article will provide information about the Anti PINK1 antibody as well the LMTK3 marker. These markers are very useful in cancer research and many other fields. There are many different uses of these markers, so you should read on to learn more. We hope you enjoy reading this article.

Anti-PINK1 antibody

The PINK1175-250 anti PINK1 antibody detects endogenous PINK1, a-synuclein, and parkin in human cells and KO mice brain. The fusion protein in both mouse brains as well as SH-SY5Y cells is almost identical to the Human PINK1 antibody and less than 30% from the Mouse DMPK. It is supplied in PBS (pH 7.4), 0.09% sodium azide, and 50% glycerol. This antibody is used to detect endogenous PINK1 gene. However, the detection limit of mRNA in mice brains is lower than that of humans.

The PINK1 antibody is suitable for immunoblotting, Western blotting and peptide ELISA. It has been used successfully in whole cell lysates from HeLa cells treated with valinomycin. It is also useful in immunoblotting and SDS–PAGE. It is a versatile, useful and widely used immunoreagent.

The LMTK3 marker, which is used to detect PINK1, is a very specific marker. Anti-PINK1 antibody are useful for research where the PINK1 protein may be involved in cancer. It is important to remember that anti-PINK1 antibody are difficult to make. Boster Bio's Anti-PINK1 antibody distinguishes it from other antibodies by using the LMTK3 mark.

The cytosol hosts the LMTK3-protein. Proteolytic cleavage produces PINK1 and it is found in cytosol. For immunocytochemistry, human neuroblastoma line cells were fixed in 4% formaldehyde (RT) for 15 minutes. PCR was performed using a 1:100 dilution of the anti-PINK1 antibody.

Boster Bio Anti PINK1 antibody uses a LMTK3 mark to recognize PINK1 inside mitochondrial membranes. It contains a kinase domain on the OMM. When it binds to LMTK3 marker markers, the antibody can detect PINK1. The antibodies are highly specific for both markers.

The PINK1 proteins contains a transmembrane helix, a linker area, and a domain for serine/threonine kinase. PINK1 is translated in the cytosol and translocated to the outer mitochondrial membrane. During normal mitochondrial function, PINK1 is rapidly cleaved and degraded, but accumulates in damaged mitochondria. Numerous proteins are phosphorylated by PINK1 at the mitochondrial top.

LMTK3 protein is highly resistant against the kinase activity PINK1 & LMTK3. Interestingly, PINK1D91-117 was recovered from both OMM and IMM fractions. This indicates that PINK1D91-171 spans the OMM. However, it does not allow the precise definition of its intramitochondrial structure.

PTEN-induced potent kinase1 is a member from the serine/threonine/protein kinase kinase kinase kinase kinase kinase kinasse family. PINK1 can be found in the brain, heart tissues, and skeletal muscles. PINK1 mutations cause mitochondrial pathology. Mutations in PINK1 cause mitochondrial disease.

Anti-LMTK3 marker

If you're a researcher looking for an anti-LMTK3 antibody, you've probably already looked at Boster Bio. Boster Bio was founded in 1993 and specializes in antibody manufacturing as well as ELISA products. Boster Bio recently expanded its product range to include PCR-related molecular biological products. Boster Bio also offers a wide variety of services for scientists and researchers, including 24 hour customer support and technical resources.