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- Table of Contents
Facts about Rhombotin-1.
Human | |
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Gene Name: | LMO1 |
Uniprot: | P25800 |
Entrez: | 4004 |
Belongs to: |
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No superfamily |
Cysteine-rich protein TTG-1; LIM domain only 1 (rhombotin 1); LMO-1; RBTN1MGC116692; RHOM1LIM domain only protein 1; rhombotin-1; TTG1T-cell translocation protein 1
Mass (kDA):
17.828 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (8224304..8268787, complement) |
Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
Nucleus.
This article will be about Steven Boster's bio, the methods and molecular markers used to detect LMO1 mutations in human cancer cells. This article will also address the clinical applications for this marker. If you have questions, feel free ask them in our comments section. We hope you find this information useful. You can use this article for your research once you've finished it.
Boster bio uses LMO1 markers in its research. LMO1 is an integral protein that can be found in membranes and has multiple extracellular exposure sites. You can use the markers to identify cells based on their expression levels. This method can detect EBER1, which is expressed during the latent phase of EBV infection. Primer 5.0 software was used to create the primers.
Recombinant Lmp1-proteins are available. The predicted molecular mass of Lmp1N, Lmp1M, and Lmp1C are 34, 38, and 37 kDa, respectively. Antisera recognize the target areas with undetectable cross-reactivity. Moreover, these antisera recognize the native Lmp1 protein from B. burgdorferi.
Patients with high levels LMP1 expression had a lower survival rate than patients who did not have the marker. Tumors with the LMP1 marker had worse survival rate than those without it. EBER1+ tumors had significantly lower OS (or PFS) than LMP1+ cancers. The study authors concluded, however, that EBER1 or LMO1 coexpression is associated with lower survival rates.
The LMO1 gene encodes a putative surface protein. Lmp1, a protein that is thought to be a surface protein, is crucial in evading host immunity and establishing persistent infection in mammalian. Lmp1 is a membraneintegral protein that has N-terminal and C-terminal regions. It also has surface-exposed areas. During murine infection, antigens against Lmp1 were produced. The three regions had different effects on the survival of spirochetes in mice immunized.
Molecular markers are molecules that have a specific role in a biological process. They can be used to identify a disease or condition. They can also be used to determine the patient's response to treatment. Molecular markers also go by the names biomarkers and signature molecules. Boster Bio uses these molecular markers in a variety applications, including DNA fingerprinting and genetic testing. However, it isn't clear what the exact function of these markers is.
More research is required to fully understand the role LMO1 plays in tumor growth. It is important to identify the gene's functions and regulatory pathways in order to determine its clinical importance. The knowledge gained can help improve the prognosis, and ultimately, the survival rate of cancer patients. Further research on LMO1's potential as a prognostic tool will be needed.
There are many polymorphisms in the LMO1 gene region, and SNPs can be associated with increased tumor susceptibility. SNPs within the LMO1 region are often associated with increased neuroblastoma risk in multiple populations, including different races. However, some SNPs are only associated with risk of neuroblastoma in a specific ethnic group. Further research is needed to fully understand the implications of these genetic variants for neuroblastoma risk.
LMP1 is expressed in latently infected B-cells. It can increase the expression of cytoskeletal and vimentin proteins, as well as promote cell migration activity. It also increases NPC cell phosphorylation of the actin bundle protein ezrin. Infection-positive B-cells expressing LMP1 have impaired release of the virus into culture supernats.
LMP1 can be used to diagnose lung cancer. It is also useful for evaluating the immune response of patients with lung cancer. LMP1 is expressed in a variety cell types and contributes towards invasive lymphocyte migration. For more information on LMO1 mediated tumor progression, please visit this website. It has been shown that this gene plays an essential role in cancer progression and inflammation.
LMP1 could be detected in exosome-like vessels using immunoelectronmicroscopy (IEM). The samples also included serum from NPC-patients and tumor-developing mouse mice treated using c666-1. After centrifugation, the supernatant of the centrifugation was transferred onto a gradient with 5% to 60% sucrose. It was then analysed using an anti LMP1 antibody.
PMID: 2501659 by McGuire E.A., et al. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein.
PMID: 2311586 by Boehm T., et al. An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.