LLGL1 Antibodies

AND LLGL1 ELISA kits, LLGL1 Proteins

Many biological assays use antibodies to detect LLGL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LLGL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LLGL1 antibodies...

We validate the specificity of these antibodies to LLGL1 by testing them on tissues known to express LLGL1 positively and negatively. Browse below to find the LLGL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LLGL1 Infographic by Boster Bio

All LLGL1 Products

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Product

Figures

Specificity

Applications

Price

Anti-LLGL1 Antibody

Human, Mouse

$405
Cat # A06016
100ul

LLGL1 (NM_004140) Human Over-expression Lysate

Human

$960
Cat # LS003996
100 µg

LLGL1 Overview

Facts about Lethal(2) giant larvae protein homolog 1.

LLGL1 3D structure. Source: alphafold

Lethal(2) giant larvae protein homolog 1 (LLGL1)

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.

Involved in axonogenesis via RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. .

Gene Information

Human
Gene Name:	LLGL1
Uniprot:	Q15334
Entrez:	3996

Family

Belongs to:

WD repeat L(2)GL family

Alternative Names

DLG4lethal giant larvae (Drosophila) homolog 1; HUGL; HUGL1; HUGL-1; Human homolog to the D-lgl gene protein; lethal giant larvae homolog 1 (Drosophila); lethal(2) giant larvae protein homolog 1; LLGL

Molecular Weight

Mass (kDA):
115.418 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (18225593..18244875)

Tissue Specificity

Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.

Subcellular Localizations

Early endosome membrane. Golgi apparatus, trans-Golgi network membrane. Golgi apparatus membrane. Cell projection, axon. Cytoplasm, cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity).

Diseases

Neoplasms
Malignant Neoplasms
Neoplasm Metastasis
Carcinoma
Cell Invasion
Tissue Adhesions
Colorectal Cancer
Malignant Paraganglionic Neoplasm
Metastatic Malignant Neoplasm To The Lymph Node
Melanoma
Neoplasm Invasiveness
Carcinogenesis
Cell Transformation, Neoplastic

Colorectal Neoplasms
Smith-magenis Syndrome
Adenoma
Tumor Progression
Malignant Neoplasm Of Breast
Colonic Neoplasms
Malignant Tumor Of Colon

Pathways

Cell Migration
Localization
Cell Adhesion
Cell Division
Asymmetric Cell Division
Cell Proliferation
Metaphase
Transport
Brain Development
Neurogenesis
Flight
Reverse Transcription
Translation

Cell Cycle
Cell Motility
Interkinetic Nuclear Migration
Segmentation
Wound Healing
Focal Adhesion Assembly
Cell-cell Adhesion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LLGL1

References

PMID: 7542763 by Strand D.J., et al. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.

PMID: 8565641 by Koyama K., et al. The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2.