LINGO1 Antibodies

AND LINGO1 ELISA kits, LINGO1 Proteins

Many biological assays use antibodies to detect LINGO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LINGO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LINGO1 antibodies...

We validate the specificity of these antibodies to LINGO1 by testing them on tissues known to express LINGO1 positively and negatively. Browse below to find the LINGO1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LINGO1 Infographic by Boster Bio

All LINGO1 Products

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Product

Figures

Specificity

Applications

Price

Anti-LINGO1 Antibody

Human, Mouse

$405
Cat # A02497
100ul

Human LINGO-1 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ96FE5
Starting from 20ug

LINGO1 (NM_032808) Human Over-expression Lysate

Human

$628
Cat # LS084894
100 µg

LINGO1 Overview

Facts about Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1.

LINGO1 3D structure. Source: alphafold

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1)

Functional part of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088).

Acts in combination with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). .

Gene Information

Human
Gene Name:	LINGO1
Uniprot:	Q96FE5
Entrez:	84894

Family

Belongs to:

No superfamily

Alternative Names

FLJ14594; LERN1; LERN1UNQ201; leucine rich repeat and Ig domain containing 1; leucine rich repeat neuronal 6A; Leucine-rich repeat and immunoglobilin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A; LINGO1; LINGO-1; LRRN6A; LRRN6Aleucine-rich repeat neuronal 6A; MGC17422

Molecular Weight

Mass (kDA):
69.876 kDA

Genomic Context


Human

Location:	15q24.3
Sequence:	15; NC_000015.10 (77613024..77820900, complement)

Tissue Specificity

Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Essential Tremor
Nervousness
Parkinson Disease
Sclerosis
Multiple Sclerosis
Spinal Cord Injuries
Movement Disorders
Intraocular Pressure Disorder
Autoimmune Reaction
Demyelinating Diseases
Encephalomyelitis
Demyelination
Experimental Autoimmune Encephalomyelitis

Hypertensive Disease
Ocular Hypertension
Trauma, Nervous System
Cns Disorder
Optic Nerve Injuries
Glaucoma
Tremor, Unspecified

Interacting Proteins

EGFR
GOLGA2
NGFR
Rtn4r
SPAG5

TRIM27

Pathways

Regeneration
Axon Regeneration
Myelination
Oligodendrocyte Differentiation
Neuroprotection
Cell Death
Pathogenesis
Localization
Brain Development
Rna Interference
Cell Adhesion
Transport
Stem Cell Differentiation

Regulation Of Oligodendrocyte Differentiation
Cell Maturation
Axon Extension
Reverse Transcription
System Development
Translation
Cell Motility

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LINGO1

References

PMID: 14686891 by Carim-Todd L., et al. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.

PMID: 14966521 by Mi S., et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.