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Protein lin-7 homolog A Antibodies
AND LIN7A ELISA kits, Protein lin-7 homolog A Proteins
Many biological assays use antibodies to detect Protein lin-7 homolog A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein lin-7 homolog A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein lin-7 homolog A antibodies...
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LIN7A Overview
Facts about Protein lin-7 homolog A.
Protein lin-7 homolog A (LIN7A)
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors in the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes which may regulate recycling and delivery of proteins to the appropriate membrane domains.
The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses in which it is recruited by beta-catenin and cadherin.
Gene Information
| Human | |
|---|---|
| Gene Name: | LIN7A |
| Uniprot: | O14910 |
| Entrez: | 8825 |
Family
| Belongs to: |
|---|
| lin-7 family |
Alternative Names
hLin-7; lin-7 homolog A (C. elegans); LIN7; LIN-7A; MALS1; MALS-1MGC148143; Mammalian lin-seven protein 1; Tax interaction protein 33; TIP-33mammalian LIN-7 1; veli-1; VELI1protein lin-7 homolog A; vertebrate LIN7 homolog 1; Vertebrate lin-7 homolog 1
Molecular Weight
Mass (kDA):
25.997 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.31 |
| Sequence: | 12; NC_000012.12 (80792520..80937915, complement) |
Tissue Specificity
Expressed in brain, testis, kidney, placenta and liver.
Subcellular Localizations
Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction. Mainly basolateral in renal epithelial cells.
Diseases
- Tissue Adhesions
- Neoplasms
- Amaurosis
- Malnutrition
- Mood Disorders
- Melanoma
- Neoplasm Invasiveness
- Manic
- Tumor Angiogenesis
- Epilepsy, Reflex
- Malignant Neoplasms
- Lymphoma
Interacting Proteins
- CASK
- FAM9B
- GOLGA2
- MPP3
- MPP5
- MPP6
- MPP7
- NOTCH2NL
- ZYX
Pathways
- Localization
- Cell Adhesion
- Cell-cell Adhesion
- Transport
- Righting Reflex
- Synapse Organization
- Cell Migration
- Receptor Clustering
- Protein Targeting
- Tube Formation
- Glycosylation
- Synaptic Transmission
- Vesicle Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIN7A
bosterbio.com/bosterbio-gene-info-cards/LIN7A
References
PMID: 9753324 by Butz S., et al. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.
PMID: 10341223 by Jo K., et al. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex.