Protein lin-54 homolog Antibodies

AND LIN54 ELISA kits, Protein lin-54 homolog Proteins

Many biological assays use antibodies to detect Protein lin-54 homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein lin-54 homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein lin-54 homolog antibodies...

We validate the specificity of these antibodies to Protein lin-54 homolog by testing them on tissues known to express LIN54 positively and negatively. Browse below to find the LIN54 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIN54 Infographic by Boster Bio

All LIN54 Products

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Anti-Protein lin-54 homolog LIN54 Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A09336
0.1 mg

LIN54 Overview

Facts about Protein lin-54 homolog.

LIN54 3D structure. Source: alphafold

Protein lin-54 homolog (LIN54)

Part of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the circumstance (PubMed:17671431, PubMed:17531812). In G0 phase, the complex binds to over 800 promoters and is required for repression of E2F target genes (PubMed:17671431, PubMed:17531812).

In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17671431, PubMed:17531812). In the complex, acts as a DNA- binding protein which binds the promoter of CDK1 in a sequence- specific manner (PubMed:19725879).

Gene Information

Human
Gene Name:	LIN54
Uniprot:	Q6MZP7
Entrez:	132660

Family

Belongs to:

lin-54 family

Alternative Names

CXCDC1; JC8.6; MIP120; Protein LIN-54

Molecular Weight

Mass (kDA):
79.494 kDA

Genomic Context


Human

Location:	4q21.22
Sequence:	4; NC_000004.12 (82924603..83012951, complement)

Subcellular Localizations

Nucleus.

Diseases

Retinoblastoma

Interacting Proteins

MYBL2
RBL2

Pathways

Cell Cycle
S Phase
Senescence
Regulation Of Cell Cycle
Dna Replication
Cellular Localization
Mitosis

Localization
Nuclear Export

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIN54

References

PMID: 17671431 by Schmit F., et al. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.

PMID: 17531812 by Litovchick L., et al. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.