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- Table of Contents
Facts about Protein lin-28 homolog B.
Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to keep the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation.
Mouse | |
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Gene Name: | Lin28b |
Uniprot: | Q45KJ6 |
Entrez: | 380669 |
Belongs to: |
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lin-28 family |
CSDD2; CSDD2protein lin-28 homolog B; FLJ16517; lin-28 homolog B (C. elegans); Lin-28.2; LIN28B; LIN-28B
Mass (kDA):
26.903 kDA
Mouse | |
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Location: | 10|10 B2 |
Sequence: | 10; |
PMID: 19211792 by Chang T.-C., et al. Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.