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LILRA4 Antibodies
AND LILRA4 ELISA kits, LILRA4 Proteins
Many biological assays use antibodies to detect LILRA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LILRA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LILRA4 antibodies...
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LILRA4 Overview
Facts about Leukocyte immunoglobulin-like receptor subfamily A member 4.
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4)
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells which have been exposed to influenza virus or cytidine- phosphate-guanosine (CpG) dinucleotides, signaling it acts as negative regulator of TLR7 and TLR9 signaling cascades (PubMed:16735691, PubMed:19564354, PubMed:24586760).
Down- modulates interferon production in response to interaction with BST2 on HIV-1 infected cells (PubMed:26172439). Activates a signaling cascade in complex with FCER1G which results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354).
Gene Information
| Human | |
|---|---|
| Gene Name: | LILRA4 |
| Uniprot: | P59901 |
| Entrez: | 23547 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD85 antigen-like family member G; CD85g antigen; CD85g; ILT7; ILT-7; ILT7MGC129598; Immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member4; LILRA4; MGC129597
Molecular Weight
Mass (kDA):
55.165 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.42 |
| Sequence: | 19; NC_000019.10 (54333185..54339162, complement) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Virus Diseases
- Autoimmune Diseases
- Autoimmune Reaction
- Leukemia
- Infective Disorder
- Influenza
- Psoriasis
- Childhood Asthma
- Acute Lymphocytic Leukemia
- Leukemia, Myelocytic, Acute
- Acute Leukemia
Interacting Proteins
- BST2
Pathways
- Immune Response
- Reverse Transcription
- Cytokine Production
- Phagocytosis
- Cell Differentiation
- Dendritic Cell Differentiation
- Monocyte Activation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LILRA4
bosterbio.com/bosterbio-gene-info-cards/LILRA4
References
PMID: 16777052 by Zhan X., et al. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry.
PMID: 16735691 by Cao W., et al. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production.