Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6)

Receptor for R-spondins which potentiates the canonical Wnt signaling pathway and acts as a mark of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors which are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to improve expression of target genes.

In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.