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LGR5 Antibodies
AND LGR5 ELISA kits, LGR5 Proteins
Many biological assays use antibodies to detect LGR5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LGR5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LGR5 antibodies...
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LGR5 Infographic by Boster Bio
All LGR5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M00239
100 μl
Cat # M00239
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00239-2
100 μg/vial
Cat # A00239-2
100 μg/vial
LGR5 Overview
Facts about Leucine-rich repeat-containing G-protein coupled receptor 5.
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5)
Receptor for R-spondins which potentiates the canonical Wnt signaling pathway and functions as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors which are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to improve expression of target genes.
In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
Gene Information
| Human | |
|---|---|
| Gene Name: | LGR5 |
| Uniprot: | O75473 |
| Entrez: | 8549 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
FEX; G protein-coupled receptor 49; GPR49; GPR49G-protein coupled receptor HG38; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; GRP49; HG38; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; Lgr5; MGC117008; orphan G protein-coupled receptor HG38
Molecular Weight
Mass (kDA):
99.998 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.1 |
| Sequence: | 12; NC_000012.12 (71439798..71586310) |
Tissue Specificity
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).
Diseases
- Malignant Neoplasms
- Neoplasms
- Colorectal Cancer
- Malignant Tumor Of Colon
- Carcinoma
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- Colonic Neoplasms
- Neoplasm Metastasis
- Adenocarcinoma
- Adenoma
- Carcinogenesis
- Cell Invasion
Pathways
- Cell Proliferation
- Pathogenesis
- Regeneration
- Cell Differentiation
- Cell Adhesion
- Cell Cycle
- Stem Cell Proliferation
- Epithelial Cell Proliferation
- Localization
- Secretion
- Cell Migration
- Tissue Homeostasis
- Endocytosis
PTMs
- Phosphorylation
- Methylation
- Deacetylation
Research Areas
- Cancer
- GPCR
- Neuroscience
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LGR5
bosterbio.com/bosterbio-gene-info-cards/LGR5
References
PMID: 9642114 by McDonald T., et al. Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily.
PMID: 9849958 by Hsu S.Y., et al. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region.