LGI1 Antibodies

AND LGI1 ELISA kits, LGI1 Proteins

Many biological assays use antibodies to detect LGI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LGI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LGI1 antibodies...

We validate the specificity of these antibodies to LGI1 by testing them on tissues known to express LGI1 positively and negatively. Browse below to find the LGI1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LGI1 Infographic by Boster Bio

All LGI1 Products

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Product

Figures

Specificity

Applications

Price

Anti-LGI1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A00850
0.1 mg

Anti-Lgi1/EPT/LGI1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A00850-1
100 μg/vial

Anti-Lgi1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M00850
100 μl/vial

LGI1 (NM_005097) Human Over-expression Lysate

Human

$628
Cat # LS009211
100 µg

LGI1 Overview

Facts about Leucine-rich glioma-inactivated protein 1.

LGI1 3D structure. Source: alphafold

Leucine-rich glioma-inactivated protein 1 (LGI1)

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit.

Ligand for ADAM22 that positively modulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in curbing the creation of MMP1/3 throughout the phosphatidylinositol 3-kinase/ERK pathway.

Gene Information

Human
Gene Name:	LGI1
Uniprot:	O95970
Entrez:	9211

Family

Belongs to:

No superfamily

Alternative Names

ADLTE; ADPAEF; ADPEAF; BB130740; epilepsy, partial; Epitempin; Epitempin-1; EPT; EPTleucine-rich glioma-inactivated protein 1; ETL1; ETL1epitempin-1; IB1099; leucine-rich, glioma inactivated 1; LGI1

Molecular Weight

Mass (kDA):
63.818 kDA

Genomic Context


Human

Location:	10q23.33
Sequence:	10; NC_000010.11 (93757809..93798174)

Tissue Specificity

Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level).

Subcellular Localizations

Secreted. Cell junction, synapse. Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.