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LEO1 Antibodies
AND LEO1 ELISA kits, LEO1 Proteins
Many biological assays use antibodies to detect LEO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LEO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LEO1 antibodies...
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LEO1 Infographic by Boster Bio
All LEO1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A06433-2
100 µg/vial
Cat # A06433-2
100 µg/vial
LEO1 Overview
Facts about RNA polymerase-associated protein LEO1.
RNA polymerase-associated protein LEO1 (LEO1)
Part of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through discussion with POLR2A CTD non- phosphorylated and'Ser-2'- and'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.
PAF1C is necessary for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Gene Information
| Human | |
|---|---|
| Gene Name: | LEO1 |
| Uniprot: | Q8WVC0 |
| Entrez: | 123169 |
Family
| Belongs to: |
|---|
| LEO1 family |
Alternative Names
Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); RDLReplicative senescence down-regulated leo1-like protein; RNA polymerase-associated protein LEO1
Molecular Weight
Mass (kDA):
75.404 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.2 |
| Sequence: | 15; NC_000015.10 (51938024..51971801, complement) |
Tissue Specificity
Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Hyperparathyroidism-jaw Tumor Syndrome
- Congenital Abnormality
- Crest Syndrome
- Parathyroid Gland Adenocarcinoma
- Leukemogenesis
- Genomic Instability
- Glioma
- Glioblastoma
- Oligodendroglioma
Interacting Proteins
- CDC73
- CTNNB1
- PAF1
- TCEA1
Pathways
- Localization
- Histone Modification
- Cell Cycle
- Methylation
- Chromatin Remodeling
- Rna Processing
- Aging
- Regulation Of Gene Expression
- Cell Division
- Replicative Senescence
- Segmentation
- Mrna Polyadenylation
- Histone Methylation
PTMs
- Phosphorylation
- Methylation
Research Areas
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LEO1
bosterbio.com/bosterbio-gene-info-cards/LEO1
References
PMID: 15791002 by Zhao L., et al. Expression of the Leo1-like domain of replicative senescence down- regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts.
PMID: 15632063 by Rozenblatt-Rosen O., et al. The parafibromin tumor suppressor protein is part of a human Paf1 complex.