LARS2 Antibodies

AND LARS2 ELISA kits, LARS2 Proteins

Many biological assays use antibodies to detect LARS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LARS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LARS2 antibodies...

We validate the specificity of these antibodies to LARS2 by testing them on tissues known to express LARS2 positively and negatively. Browse below to find the LARS2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LARS2 Infographic by Boster Bio

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LARS2 (NM_015340) Human Over-expression Lysate

Human

$628
Cat # LS023395
100 µg

LARS2 Overview

Facts about Probable leucine--tRNA ligase, mitochondrial.

LARS2 3D structure. Source: alphafold

Probable leucine--tRNA ligase, mitochondrial (LARS2)

Gene Information

Human
Gene Name:	LARS2
Uniprot:	Q15031
Entrez:	23395

Family

Belongs to:

class-I aminoacyl-tRNA synthetase family

Alternative Names

EC 6.1.1; EC 6.1.1.4; KIAA0028leucine tRNA ligase 2, mitocondrial; leucine translase; Leucine--tRNA ligase; leucyl-tRNA synthetase 2, mitochondrial; LEURS; MGC26121; probable leucyl-tRNA synthetase, mitochondrial

Molecular Weight

Mass (kDA):
101.976 kDA

Genomic Context


Human

Location:	3p21.31
Sequence:	3; NC_000003.12 (45388564..45549407)

Tissue Specificity

Ubiquitously expressed, but highest expression in tissues with high metabolic rates, such as skeletal muscle, heart, and kidney.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Acidosis
Carcinogenesis
Carcinoma
Melas Syndrome
Neoplasms
Acidosis, Lactic
Malignant Squamous Cell Neoplasm
Mitochondrial Encephalomyopathies
Postmortem Changes
Schizophrenia
Head And Neck Carcinoma

Nasopharyngitis
Mitochondrial Myopathies
Cancer Of Nasopharynx
Myopathy
Major Depressive Disorder
Loss Of Chromosome 3p
Encephalopathies

Pathways

Methylation
Glucose Homeostasis
Translation
Mitochondrial Translation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LARS2

References

PMID: 20194621 by Li R., et al. Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes.

PMID: 23541342 by Pierce S.B., et al. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome.