This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
LAPTM4B Antibodies
AND LAPTM4B ELISA kits, LAPTM4B Proteins
Many biological assays use antibodies to detect LAPTM4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LAPTM4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LAPTM4B antibodies...
Previous: Septin9
Next: TBC1D2
LAPTM4B Infographic by Boster Bio
All LAPTM4B Products
Product
Figures
Specificity
Applications
Price
LAPTM4B Overview
Facts about Lysosomal-associated transmembrane protein 4B.
Lysosomal-associated transmembrane protein 4B (LAPTM4B)
Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation.
Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) into the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567).
Gene Information
| Human | |
|---|---|
| Gene Name: | LAPTM4B |
| Uniprot: | Q86VI4 |
| Entrez: | 55353 |
Family
| Belongs to: |
|---|
| LAPTM4/LAPTM5 transporter family |
Alternative Names
LAPTM4beta; LC27; lysosomal associated protein transmembrane 4 beta; lysosomal protein transmembrane 4 beta; lysosomal-associated transmembrane protein 4B; Lysosome-associated transmembrane protein 4-beta
Molecular Weight
Mass (kDA):
35.123 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q22.1 |
| Sequence: | 8; NC_000008.11 (97775788..97853013) |
Subcellular Localizations
Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen.
Diseases
- Carcinoma
- Malignant Neoplasms
- Liver Carcinoma
- Neoplasms
- Neoplasm Metastasis
- Liver Neoplasms
- Cell Transformation, Neoplastic
- Cell Invasion
- Malignant Neoplasm Of Gallbladder
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Ovarian Neoplasm
Interacting Proteins
- ABCB1
- EGFR
- EXOC4
- NAALADL2
- PIK3R1
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Cycle
- Regulation Of Cell Cycle
- Localization
- Cell Growth
- Autophagy
- Cell Adhesion
- Cell Migration
- Induction Of Apoptosis
- Cellular Response To Nutrient
- Cell Death
PTMs
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LAPTM4B
bosterbio.com/bosterbio-gene-info-cards/LAPTM4B
References
PMID: 12902989 by Shao G.-Z., et al. Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma.
PMID: 21224396 by Vergarajauregui S., et al. LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.