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- Table of Contents
Facts about Ragulator complex protein LAMTOR5.
Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is subsequently activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway.
Human | |
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Gene Name: | LAMTOR5 |
Uniprot: | O43504 |
Entrez: | 10542 |
Belongs to: |
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LAMTOR5 family |
HBV X-interacting protein; HBX-interacting protein; hepatitis B virus x interacting protein; hepatitis B virus x-interacting protein (9.6kD); MGC71071; XIPhepatitis B virus X-interacting protein
Mass (kDA):
9.614 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (110401253..110407924, complement) |
Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
Cytoplasm. Lysosome.
PMID: 9499022 by Melegari M., et al. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication.
PMID: 12773388 by Marusawa H., et al. HBXIP functions as a cofactor of survivin in apoptosis suppression.