Kallikrein-8 Antibodies

Kallikrein-8 (KLK8)

Serine protease that's capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity.

Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is needed for memory acquisition and synaptic plasticity.

Gene Information

Human
Gene Name:	KLK8
Uniprot:	O60259
Entrez:	11202

Family

Belongs to:
peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.118; hK8; HNP; kallikrein 8 (neuropsin/ovasin); Kallikrein 8; kallikrein-related peptidase 8; KLK8 protein type 1; KLK8 protein type 2; KLK8; neuropsin type 1; neuropsin type 2; Neuropsin; NP; NRPN; Ovasin; PRSS19; PRSS19kallikrein-8; Serine protease 19; Serine protease TADG-14; TADG14neuropsin; Tumor-associated differentially expressed gene 14 protein

Molecular Weight

Mass (kDA):
28.048 kDA

Genomic Context

Human
Location:	19q13.41
Sequence:	19; NC_000019.10 (50996008..51001702, complement)

Tissue Specificity

Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.

Subcellular Localizations

Secreted. Cytoplasm. Shows a cytoplasmic distribution in the keratinocytes.

Diseases

• Malignant Neoplasms
• Nervousness
• Neoplasms
• Carcinoma
• Malignant Neoplasm Of Ovary
• Ovarian Neoplasm
• Malignant Neoplasm Of Breast
• Dermatologic Disorders
• Cell Invasion
• Kindling, Neurologic
• Malignant Squamous Cell Neoplasm
• Adenocarcinoma
• Tissue Adhesions

• Psoriasis
• Epilepsy
• Dermatitis
• Malignant Neoplasm Of Lung
• Hyperkeratosis
• Inflammation
• Dermatitis, Atopic

Interacting Proteins

• NOTCH2NL
• ZDHHC17

Pathways

• Pathogenesis
• Localization
• Secretion
• Cell Adhesion
• Proteolysis
• Keratinocyte Differentiation
• Cell Proliferation
• Cell Death
• Keratinocyte Proliferation
• Tissue Development
• Cell Differentiation
• Transport
• Keratinization

• Long-term Synaptic Potentiation
• Cell Migration
• Brain Development
• Aging
• Reverse Transcription
• Chemotaxis
• Cell Motility

PTMs

• Cleavage
• Glycosylation

• Amination
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLK8

Boster Bio - Best Uses Of The KLK8 Marker

This Boster Bio review will give you helpful suggestions to improve your experiments. The Boster Bio troubleshooting guide will help you identify and eliminate numerous sources of error. Troubleshooting guides are especially helpful when you're having difficulty carrying out the Boster Bio experiment. These guides also provide information on how to use Boster Bio's optimization tools to boost your results. Every researcher has their own mistakes. Every experiment is not perfect. These errors can be minimized or eliminated by using appropriate control methods.

Boster Bio troubleshooting guides

The Boster Bio troubleshooting guides for KLK8 include sample preparation optimization tips, sample preparation, and protocol specifics. Make sure you follow the flow cytometry protocols prior to you start your experiment. Titration is an essential step to maximize the signal from a specific antibody. The guide provides the recommended concentration of antibodies and includes information on sample preparation. Titration is the process through which an antibody gets diluted until it reaches a specific concentration.

Boster Bio KLK8 Marker

The Boster Bio KLK8 Marker is a monoclonal antibody that has high sensitivity and has been tested in a variety of different applications that include IHC. It is also used in IHC applications in squamous cells. We will go over its most efficient uses in this article. Let's begin by discussing its past. Boster was founded by Steven Boster in 1993. He was dubbed "he that converts science into a lavatory."

Telbivudine may be a better alternative.

Telbivudine is a possible alternative for patients suffering from certain cancers such as non-small-cell lung carcinoma. Telbivudine is a deterrent to the synthesis of second strand DNA, a process that is essential for the growth of tumors. Telbivudine has no adverse effects on fetuses or embryos in animals. At 600 micromolar concentrations, Telbivudine didn't cause any harm to HepG2 cell.

In an investigation of 83 patients with chronic hepatitis B treatment, telbivudine significantly increased the levels of serum KLK8. KLK8 levels as well as eGFR significantly increased after two years of telbivudine treatments. Telbivudine could have a greater impact on eGFR that other treatments.

However, there isn't a direct relationship between KLK8 and eGFR. Telbivudine treatment led to significant increase in serum KLK8 levels. Positive correlations were observed between BH levels and post-treatment levels. However, KLK8 should be adjusted to account for BH when looking at post-treatment levels of KLK8 against other clinical factors.

In this study, telbivudine was given to 139 patients, with the control group comprising 102 patients. The antiviral treatment started the week between 12 and 27 gestation. Table 1 shows the characteristics of the baseline participants. Telbivudine was administered simultaneously as the control group. Telbivudine was also given to 104 patients, who were pregnant and exhibited the KLK8 marker.

Although telbivudine is a highly effective treatment for chronic hepatitis B infection, it has not been demonstrated to be safe for perinatal transmission the disease. There are numerous other possible negative side effects of the use of telbivudine. These include liver cancer. The drug is currently used to prevent the perinatal transmission of Hepatitis B virus and could be beneficial for patients who have the KLK8 marker.