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Kallikrein-8 Antibodies
AND KLK8 ELISA kits, Kallikrein-8 Proteins
Many biological assays use antibodies to detect Kallikrein-8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kallikrein-8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kallikrein-8 antibodies...
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KLK8 Infographic by Boster Bio
All KLK8 Products
Product
Figures
Specificity
Applications
Price
Human KLK8/Kallikrein-8 ELISA Kit PicoKine®
2 Citations 9 Q&As
Human
ELISA
$750
Cat # EK0819
96 wells/kit, with removable strips.
Cat # EK0819
96 wells/kit, with removable strips.
Dog, Human, Monkey, Mouse, Rat
IF, WB
$523
Cat # M03901-1
100 µl
Cat # M03901-1
100 µl
Dog, Human, Monkey
IF, IHC, WB
$523
Cat # M03901
100 µl
Cat # M03901
100 µl
Human
Flow Cytometry, IHC, WB
$523
Cat # M03901-2
100 µl
Cat # M03901-2
100 µl
KLK8 Overview
Facts about Kallikrein-8.
Kallikrein-8 (KLK8)
Serine protease that's capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity.
Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is needed for memory acquisition and synaptic plasticity.
Gene Information
| Human | |
|---|---|
| Gene Name: | KLK8 |
| Uniprot: | O60259 |
| Entrez: | 11202 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
EC 3.4.21; EC 3.4.21.118; hK8; HNP; kallikrein 8 (neuropsin/ovasin); Kallikrein 8; kallikrein-related peptidase 8; KLK8 protein type 1; KLK8 protein type 2; KLK8; neuropsin type 1; neuropsin type 2; Neuropsin; NP; NRPN; Ovasin; PRSS19; PRSS19kallikrein-8; Serine protease 19; Serine protease TADG-14; TADG14neuropsin; Tumor-associated differentially expressed gene 14 protein
Molecular Weight
Mass (kDA):
28.048 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.41 |
| Sequence: | 19; NC_000019.10 (50996008..51001702, complement) |
Tissue Specificity
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes.
Subcellular Localizations
Secreted. Cytoplasm. Shows a cytoplasmic distribution in the keratinocytes.
Diseases
- Malignant Neoplasms
- Nervousness
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Malignant Neoplasm Of Breast
- Dermatologic Disorders
- Cell Invasion
- Kindling, Neurologic
- Malignant Squamous Cell Neoplasm
- Adenocarcinoma
- Tissue Adhesions
Interacting Proteins
- NOTCH2NL
- ZDHHC17
Pathways
- Pathogenesis
- Localization
- Secretion
- Cell Adhesion
- Proteolysis
- Keratinocyte Differentiation
- Cell Proliferation
- Cell Death
- Keratinocyte Proliferation
- Tissue Development
- Cell Differentiation
- Transport
- Keratinization
PTMs
- Cleavage
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLK8
bosterbio.com/bosterbio-gene-info-cards/KLK8
References
PMID: 9714609 by Yoshida S., et al. Sequence analysis and expression of human neuropsin cDNA and gene.
PMID: 10485494 by Underwood L.J., et al. Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.
2 Publications of Boster Kallikrein-8 Antibodies & ELISA Kits
- PubMed ID: 10.1186/s13195-021-00945-x, Is kallikrein-8 a blood biomarker for detecting amnestic mild cognitive impairme...
- PubMed ID: 29505099 , Higher levels of kallikrein-8 in female brain may increase the risk for Alzheime...
*More publications can be found for each product on its corresponding product page