This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Kin of IRRE-like protein 3.
Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably functions as a homophilic adhesion molecule that boosts trans-cellular interactions and stabilize mossy fiber filipodia contact and following synapse formation (PubMed:26575286).
Mouse | |
---|---|
Gene Name: | Kirrel3 |
Uniprot: | Q8BR86 |
Entrez: | 67703 |
Belongs to: |
---|
immunoglobulin superfamily |
KIAA1867MGC126824; kin of IRRE like 3 (Drosophila); Kin of irregular chiasm-like protein 3; kin of IRRE-like protein 3; KIRRE; Kirrel3; KIRREPRO4502; mKIRRE; MRD4; NEPH2; NEPH2MGC126850; nephrin-like 2; Nephrin-like protein 2
Mass (kDA):
85.405 kDA
Mouse | |
---|---|
Location: | 9|9 A4 |
Sequence: | 9; |
Expressed mainly in adult brain, bone marrow and stromal cells (PubMed:12665856). Expressed in diverse regions of the brain, including the cortex, hippocampus, striatum, olfactory bulb and cerebellum (PubMed:15908127, PubMed:26283919). In brain, expressed in pontine nucleus neurons (at protein level) (PubMed:21241806). In hippocampus, produced in both the dentate granule neurons and the GABAergic neurons, but not the CA3 neurons (PubMed:26575286). Expressed in subpopulations of vomeronasal sensory neurons (PubMed:23637329). Expressed in a subset of neurons in dorsal root ganglia (PubMed:18752272).
PMID: 12665856 by Ueno H., et al. A stromal cell-derived membrane protein that supports hematopoietic stem cells.
PMID: 15843475 by Gerke P., et al. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases.