Lysine-specific histone demethylase 1B (Kdm1b)

Histone demethylase that demethylates'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis.

Acts by oxidizing the substrate by FAD to create the corresponding imine that's subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.