KSR2 Antibodies

AND KSR2 ELISA kits, KSR2 Proteins

Many biological assays use antibodies to detect KSR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KSR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KSR2 antibodies...

We validate the specificity of these antibodies to KSR2 by testing them on tissues known to express KSR2 positively and negatively. Browse below to find the KSR2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KSR2 Infographic by Boster Bio

All KSR2 Products

Product

Figures

Specificity

Applications

Price

Anti-Kinase suppressor of Ras 2 KSR2 Antibody

7 Q&As

Human, Mouse

IF, WB

$360
Cat # A06876
100 µl

KSR2 Colorimetric Cell-Based ELISA

Human, Mouse

ELISA

$480
Cat # EKC1857
1 kit, containing one 96-well plate and all necessary reagents

Anti-Ksr2 (I694) Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A06876-1
100ul

KSR2 (NM_173598) Human Over-expression Lysate

Human

$960
Cat # LS283455
100 µg

KSR2 Overview

Facts about Kinase suppressor of Ras 2.

Kinase suppressor of Ras 2 (KSR2)

Location-regulated scaffold connecting MEK to RAF.
Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro).

Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling.

Gene Information

Human
Gene Name:	KSR2
Uniprot:	Q6VAB6
Entrez:	283455

Family

Belongs to:

protein kinase superfamily

Alternative Names

FLJ25965; hKSR2; kinase suppressor of ras 2; kinase suppressor of Ras-2

Molecular Weight

Mass (kDA):
107.632 kDA

Genomic Context


Human

Location:	12q24.22-q24.23
Sequence:	12; NC_000012.12 (117453012..117968990, complement)

Tissue Specificity

Mainly expressed in brain and kidney.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein.

Diseases

Neoplasms
Obesity
Carcinoma
Malignant Neoplasms
Myeloid Leukemia
Leukemia
Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Insulin Resistance
Leukemia, Myelocytic, Acute
Mammary Neoplasms
Ovarian Neoplasm
Esophageal Neoplasms

Cell Invasion
Neuroblastoma
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Mucinous Adenocarcinoma
Hyperphagia
Diabetes Mellitus

Interacting Proteins

CDC37
FKBP5
HSP90AA1

Pathways

Reverse Transcription
Cell Proliferation
Regulation Of Cell Proliferation
Cell Differentiation
Oxidative Phosphorylation
Fatty Acid Oxidation
Energy Homeostasis
Rna Interference

Localization
Glycolysis

PTMs

Phosphorylation

Oxidation

Dephosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KSR2

References

PMID: 12975377 by Channavajhala P.L., et al. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling.

PMID: 16039990 by Channavajhala P.L., et al. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation.