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- Table of Contents
Facts about Keratin, type II cytoskeletal 78.
Human | |
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Gene Name: | KRT78 |
Uniprot: | Q8N1N4 |
Entrez: | 196374 |
Belongs to: |
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intermediate filament family |
CK-78; cytokeratin-78; Kb40; keratin 5b; keratin 78; keratin-78; type II cytoskeletal 78
Mass (kDA):
56.866 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (52837804..52848994, complement) |
In non-keratinising esophageal and vaginal epithelium, strongly expressed in the basal and parabasal/lower suprabasal cell layers with considerably decreased expression in the mid/upper suprabasal layers (at protein level) (PubMed:26340985). A similar gradient from basal to lower suprabasal layers is seen in the partially keratinised dorsal tongue epithelium, in the scalp and in the plantar epidermis (at protein level) (PubMed:26340985). Extension of expression into the suprabasal compartments is distinctly more pronounced in non- keratinising epithelia than in keratinising epithelia and epidermis (at protein level) (PubMed:26340985). In scalp sections, present in the interfollicular epidermis and infundibulum including the entire outer root sheath of the hair follicles and also in the sebocytes (at protein level) (PubMed:26340985). In sweat glands, expressed in peripheral and luminal cells of the lower duct and in peripheral cells of the middle/upper duct with no expression observed in luminal cells (at protein level) (PubMed:26340985). In embryos at the 14th week of pregnancy, detected in basal and parabasal layers but is absent from the uppermost epidermal layer (at protein leve
PMID: 11683385 by Hesse M., et al. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.
PMID: 15737194 by Rogers M.A., et al. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.