KRT74 Antibodies

AND KRT74 ELISA kits, KRT74 Proteins

Many biological assays use antibodies to detect KRT74, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KRT74 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KRT74 antibodies...

We validate the specificity of these antibodies to KRT74 by testing them on tissues known to express KRT74 positively and negatively. Browse below to find the KRT74 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KRT74 Infographic by Boster Bio

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KRT74 (NM_175053) Human Over-expression Lysate

Human

$960
Cat # LS121391
100 µg

KRT74 Overview

Facts about Keratin, type II cytoskeletal 74.

KRT74 3D structure. Source: alphafold

Keratin, type II cytoskeletal 74 (KRT74)

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

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Gene Information

Human
Gene Name:	KRT74
Uniprot:	Q7RTS7
Entrez:	121391

Family

Belongs to:

intermediate filament family

Alternative Names

HTSS2; K6IRS4; KRT5C; KRT6IRS4; KRT74 keratin 74

Molecular Weight

Mass (kDA):
57.865 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (52565782..52573843, complement)

Tissue Specificity

Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level).

Diseases

Hair Diseases
Wooly Hair
Hypotrichosis

Pathways

Hair Follicle Development
Pathogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KRT74

References

PMID: 12648212 by Langbein L., et al. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath- specific type II epithelial keratins of the human hair follicle.

PMID: 11683385 by Hesse M., et al. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.