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- Table of Contents
Facts about GTPase KRas.
Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells at a ZNF304-dependent manner (PubMed:24623306). .
Human | |
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Gene Name: | KRAS |
Uniprot: | P01116 |
Entrez: | 3845 |
Belongs to: |
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small GTPase superfamily |
cellular c-Ki-ras2 proto-oncogene; c-Ki-ras; C-K-RAS; GTPase KRas; KI-RAS; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; K-Ras 2; K-ras p21 protein; KRAS1; K-RAS2A; K-RAS2B; KRAS2NS3; K-RAS4A; K-RAS4B; NS; oncogene KRAS2; PR310 c-K-ras oncogene; RASK2c-Kirsten-ras protein; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Mass (kDA):
21.656 kDA
Human | |
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Location: | 12p12.1 |
Sequence: | 12; NC_000012.12 (25205246..25250929, complement) |
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol.
PMID: 6308466 by McGrath J.P., et al. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.
PMID: 6308465 by Shimizu K., et al. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.