KRT2 Antibodies

AND KRT2 ELISA kits, KRT2 Proteins

Many biological assays use antibodies to detect KRT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KRT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KRT2 antibodies...

We validate the specificity of these antibodies to KRT2 by testing them on tissues known to express KRT2 positively and negatively. Browse below to find the KRT2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KRT2 Infographic by Boster Bio

All KRT2 Products

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Anti-Keratin-pan KRT2 Antibody

1 Citations

Human, Mouse, Rat

IHC, WB

$399
Cat # A05667
100μl

Anti-Cytokeratin 2e/KRT2 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A05667-2
100 µg/vial

KRT2 Overview

Facts about Keratin, type II cytoskeletal 2 epidermal.

KRT2 3D structure. Source: alphafold

Keratin, type II cytoskeletal 2 epidermal (KRT2)

Probably contributes to terminal cornification (PubMed:1380918). Connected with keratinocyte activation, proliferation and keratinization (PubMed:12598329).

Plays a role in the creation of the epidermal barrier on plantar skin (By similarity). .

Gene Information

Human
Gene Name:	KRT2
Uniprot:	P35908
Entrez:	3849

Family

Belongs to:

intermediate filament family

Alternative Names

CK-2e; cytokeratin-2e; epidermal ichthyosis bullosa of Siemens; Epithelial keratin-2e; K2e; keratin 2; keratin 2A (epidermal ichthyosis bullosa of Siemens); keratin, type II cytoskeletal 2 epidermal; Keratin-2 epidermis; keratin-2e; KRT2AMGC116967; KRT2EMGC116968; KRTE; Type-II keratin Kb2

Molecular Weight

Mass (kDA):
65.433 kDA

Genomic Context


Human

Location:	12q13.13
Sequence:	12; NC_000012.12 (52644558..52652211, complement)

Tissue Specificity

Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization.

Diseases

Ichthyoses
Ichthyosis Bullosa Of Siemens
Hyperkeratosis
Bullous Congenital Ichthyosiform Erythroderma (disorder)
Bulla
Exfoliative Dermatitis
Dermatologic Disorders
Ichthyosiform Erythroderma, Congenital
Skin Diseases, Vesiculobullous
Congenital Ichthyosis
Malignant Squamous Cell Neoplasm

Disorder Of Keratinization
Inflammation
Carcinoma
Exanthema
Malignant Neoplasms
Neoplasms

Interacting Proteins

KRT13
KRT15
KRT19
KRT31
KRT38

KRT40

Pathways

Keratinization
Gene Conversion
Cornification
Keratinocyte Differentiation

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KRT2

References

PMID: 1380918 by Collin C., et al. Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation.

PMID: 9804344 by Smith F.J.D., et al. Genomic organization and fine mapping of the keratin 2e gene (KRT2E): K2e V1 domain polymorphism and novel mutations in ichthyosis bullosa of Siemens.

1 Publications of Boster KRT2 Antibodies & ELISA Kits

PubMed ID: 24142153 , Ovalbumin enhances YKL-40, IL-5, GM-CSF, and eotaxin expression simultaneously i...

*More publications can be found for each product on its corresponding product page