KMT5B Antibodies

AND KMT5B ELISA kits, KMT5B Proteins

Many biological assays use antibodies to detect KMT5B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT5B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT5B antibodies...

We validate the specificity of these antibodies to KMT5B by testing them on tissues known to express KMT5B positively and negatively. Browse below to find the KMT5B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KMT5B Infographic by Boster Bio

All KMT5B Products

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Anti-SUV420H1 KMT5B Antibody

Human, Mouse, Rat

$405
Cat # A09578
100ul

SUV420h1 (KMT5B) (NM_016028) Human Over-expression Lysate

Human

$628
Cat # LS051111
100 µg

KMT5B Overview

Facts about Histone-lysine N-methyltransferase KMT5B.

KMT5B 3D structure. Source: alphafold

Histone-lysine N-methyltransferase KMT5B (KMT5B)

Histone methyltransferase that especially trimethylates'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression.

Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the organization of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 through its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).

Gene Information

Human
Gene Name:	KMT5B
Uniprot:	Q4FZB7
Entrez:	51111

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

Histone-lysine N-methyltransferase KMT5B

Molecular Weight

Mass (kDA):
99.188 kDA

Genomic Context


Human

Location:	11q13.2
Sequence:	11; NC_000011.10 (68154863..68213899, complement)

Subcellular Localizations

Nucleus. Chromosome. Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).

Diseases

Mental retardation, autosomal dominant 51 (MRD51)

Interacting Proteins

Ncoa2

PTMs

Isopeptide bond

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT5B

References

PMID: 11401438 by Twells R.C.J., et al. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13.

PMID: 16322686 by Tryndyak V.P., et al. Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins.