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KMT2A Antibodies
AND KMT2A ELISA kits, KMT2A Proteins
Many biological assays use antibodies to detect KMT2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2A antibodies...
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KMT2A Overview
Facts about Histone-lysine N-methyltransferase 2A.
Histone-lysine N-methyltransferase 2A (KMT2A)
Histone methyltransferase that plays a vital role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of'Lys-4' of histone H3 (H3K4me) complex and acetylation of'Lys-16' of histone H4 (H4K16ac).
From the MLL1/MLL complex, it specifically mediates H3K4me, a particular tag for epigenetic transcriptional activation (PubMed:12453419, PubMed:20677832, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to acquire whole methyltransferase activity (PubMed:19187761, PubMed:26886794).
Gene Information
| Human | |
|---|---|
| Gene Name: | KMT2A |
| Uniprot: | Q03164 |
| Entrez: | 4297 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
ALL1; ALL-1MLL/GAS7; CXXC7TET1-MLL; CXXC-type zinc finger protein 7; EC 2.1.1.43; HRXFLJ11783; HTRX; HTRX1MLL-AF4 der(11) fusion protein; KMT2ACDK6/MLL fusion protein; Lysine N-methyltransferase 2A; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL1; MLL1A; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Trithorax-like protein; TRX1histone-lysine N-methyltransferase MLL; Zinc finger protein HRX
Molecular Weight
Mass (kDA):
431.764 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (118436492..118526832) |
Tissue Specificity
Heart, lung, brain and T- and B-lymphocytes.
Subcellular Localizations
Nucleus.; [MLL cleavage product N320]: Nucleus.; [MLL cleavage product C180]: Nucleus. Localizes to a diffuse nuclear pattern when not associated with MLL cleavage product N320.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Chromosomal Translocation
- Acute Lymphocytic Leukemia
- Malignant Neoplasms
- Neoplasms
- Cytogenetic Abnormality
- Acute Leukemia
- Leukemogenesis
- Cell Transformation, Neoplastic
- Acute Monocytic Leukemia
- Dysmyelopoietic Syndromes
Interacting Proteins
- AR
- Arntl
- CDC73
- Clock
- Crebbp
- CTR9
- HIST1H3A
- KAT6A
- KAT8
- PAF1
Pathways
- Methylation
- Pathogenesis
- Localization
- Cell Cycle
- Interphase
- Cell Proliferation
- Dna Methylation
- Histone Methylation
- Metaphase
- Dna Repair
- Cell Growth
- Cell Death
- Cell Differentiation
PTMs
- Methylation
- Cleavage
- Phosphorylation
- Acetylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2A
bosterbio.com/bosterbio-gene-info-cards/KMT2A
References
PMID: 1423624 by Tkachuk D.C., et al. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
PMID: 8703835 by Nilson I., et al. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.