Kallikrein-11 Antibodies

Kallikrein-11 (KLK11)

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Gene Information

Human
Gene Name:	KLK11
Uniprot:	Q9UBX7
Entrez:	11012

Family

Belongs to:
peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.-; EC 3.4.21.4; Hippostasin; hK11; Kallikrein 11; kallikrein-related peptidase 11; KLK11; MGC33060; PRSS20kallikrein-11; Serine protease 20; TLSPhippostasin; Trypsin-like protease

Molecular Weight

Mass (kDA):
31.059 kDA

Genomic Context

Human
Location:	19q13.41
Sequence:	19; NC_000019.10 (51022231..51027991, complement)

Tissue Specificity

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).

Subcellular Localizations

[Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Prostate
• Prostatic Neoplasms
• Carcinoma
• Lung Neoplasms
• Benign Prostatic Hypertrophy
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Ovary
• Malignant Neoplasm Of Breast
• Ovarian Neoplasm
• Adenocarcinoma

• Prostatic Hyperplasia
• Non-small Cell Lung Carcinoma
• Mammary Neoplasms
• Epithelial Ovarian Cancer
• Dermatitis, Atopic
• Nervousness

Pathways

• Localization
• Reverse Transcription
• Pathogenesis
• Cell Proliferation
• Cell Cycle
• Tissue Remodeling
• Zymogen Activation

• Proteolysis
• Angiogenesis

PTMs

• Cleavage

• Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLK11

Boster Bio - Best Uses Of The KLK11 Marker

Boster Bio: KLK11 Marker can be used with different types of antibodies. Boster Bio has validated each antibody using WB, ICC and Immunofluorescence. Each antibody has been validated across different platforms and is proven to have high affinity and specificity. Boster Bio rewards early reviewers with product credits. This program is accessible to all scientists from around the world.

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and Immunofluorescence

The process of validation for an antibody is critical for the accuracy of the data obtained. All antibodies are validated by Boster on WB, IHC and ICC. While WB is not a perfect instrument, it is an extremely effective method of validation. Many studies using antibodies still employ antibodies that have not been validated. This could lead to inaccurate results.

WB is an important initial screen to determine the specificity of an antibody. WB is used by IHC and ICC to detect the expression of proteins and determine if antibodies are specific. Researchers can analyze their results in comparison to other methods, such as IHC. The main difference between WB and IHC is that WB has the advantage of offering more detailed analysis of protein distribution, while ICC and IHC make use of single cells.

Generally, a secondary antibody must be used at low levels. The high concentrations of these antibodies produce significant background noise. The standard dilution of an antibody in this concentration range is 1:1000. For bright staining and readings with too background, higher dilutions may need to be used. The secondary antibody should be incubated over night at 4°C.

Both WB and ICC require that the samples be prepared. The samples need to undergo preservation of tissue which is essential to perform IHC. ICC however, on the other hand, uses individual cells. The samples are subjected to additional procedures, like formaldehyde, which blocks epitopes, and reduces antigen-antibody interaction. The further processing helps to identify the epitopes of antigens which can further enhance the accuracy of the results.

Boster provides high-affinity primary antibodies

To identify the best antibody to detect the KLK11 marker, you must first understand how flow cytometry works. The process involves the examination of the samples, which could be either particles or cells. Boster offers monoclonal aswell and polyclonal primary antibodies, which have high affinity against the KLK11 marker. These antibodies are often reviewed, and have been produced continuously for more than 25 years.

The history of Steven Boster

In 1993, Steven Boster developed his first product which was a line of ELISA kits. The product line was followed by a myriad of primary antibodies. Boster was the largest Chinese company selling catalogs of antibodies at the end of the 1990s. PicoKine is a unique ELISA platform that Boster developed using trade secrets. This platform offers high-sensitivity ELISA kits. He also became a highly recognized and respected speaker in the scientific community.

Applications that are typical

This protein was discovered to be highly expressed in cancer cells as well as chemoresistant patients. Knockdown of the KLK11 gene prevented this resistance by blocking the PI3K/AKT signaling pathway. These findings have been confirmed by numerous studies. Below are the most commonly used uses of KLK11 markers. R&D Systems produces this protein. It is related to isoform 1.

This marker activates S6K1 and 4EBP1 to stimulate protein synthesis and hypertrophy. Hypertrophia can be seen in cardiomyocytes that express KLK11. A number of studies have proven that KLK11 could be a factor in the development of cardiac hypertrophy. KLK11 could be a possible therapeutic target in the treatment of cardiac hypertrophy. Further research must be done to determine if the KLK11 protein is a therapeutic target in this disease.

This protein is extremely useful in a variety of applications. It can be used to screen several drugs simultaneously. It is a biomarker, which can be used to identify human cancers. Cloning with a molecular engine has numerous benefits and can be used to pinpoint specific tumor targets. Researchers will be able better determine the most effective treatment methods studying the molecular structure of the marker. Additionally, it's an excellent biomarker to detect different kinds of cancer.

The KLK11 gene is found in a variety of tissues which includes the epidermis. It is present in large quantities in the epidermis as well as appendages of the skin. It was discovered to be co-expressed in the epidermis of the skin and its appendages with SPINK5 which is believed to play a role inhibiting SC serine protease activity. It is also linked to Netherton syndrome, which manifests by excessive sweat production as well as dryness and other symptoms.

The KLK11 gene encodes the serine protease, that is part of human tissue Kallikrein. It is encoded in the KLK11 genome and consists of two forms: isoform 1. It contains an peptide signalling the signal and isoform 2, which is the mature chain. The 32-amino acid segment of the mature chain is located before the residue 1 in isoform 1. It has been identified as a promising biomarker for the diagnosis of cancer and prognosis.