KiSS-1 receptor Antibodies

KiSS-1 receptor (Kiss1r)

Receptor for metastin, a C-terminally amidated peptide of KiSS1.

KiSS1 is a metastasis suppressor protein.

Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone structure and for puberty.

Gene Information

Rat
Gene Name:	Kiss1r
Uniprot:	Q924U1
Entrez:	78976

Family

Belongs to:
G-protein coupled receptor 1 family

Alternative Names

AXOR12; AXOR12hypogonadotropin-1; G protein-coupled receptor 54; GPR54; GPR54kiSS-1R; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; HOT7T175; Hypogonadotropin-1; KISS1 receptor; kiSS-1 receptor; KiSS1R; KiSS-1R; Kisspeptins receptor; Metastin Receptor; OT7T175

Molecular Weight

Mass (kDA):
42.889 kDA

Genomic Context

Rat
Location:	7q11
Sequence:	7;

Tissue Specificity

Highest expression levels in the cerebrum and cecum. Moderate expression in the ovary, colon and placenta. Low levels in the uterus, small intestine, and thymus. Expressed only moderately in the placenta. No expression in kidney tissues. Has a complex and abundant central nervous system expression pattern. Expressed in brain regions such as pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex, frontal cortex, and striatum. No expression in the cerebellum. Persistent expression is detected in hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female. Hypothalamic expression changed throughout the estrus cycle and is significantly increased after gonadectomy, a rise that is prevented by sex steroid replacement both in males and females.

Diseases

• Hypogonadism
• Hypogonadotropic Hypogonadism
• Neoplasm Metastasis
• Malignant Neoplasms
• Neoplasms
• Pituitary Diseases
• Idiopathic Hypogonadotropic Hypogonadism
• Kallmann Syndrome
• Precocious Puberty
• Cell Invasion
• Carcinoma
• Infertility

• Anosmia
• Melanoma
• Neoplasm Invasiveness
• Delayed Puberty
• Malignant Neoplasm Of Breast
• Amenorrhea
• Tumor Progression

Pathways

• Secretion
• Gonadotropin Secretion
• Ovulation
• Hormone Secretion
• Localization
• Spermatogenesis
• Cell Migration
• Regulation Of Gonadotropin Secretion
• Pathogenesis
• Cell Motility
• Cell Proliferation
• Chemotaxis
• Angiogenesis

• Lactation
• Vasoconstriction
• Estrus
• Insulin Secretion
• Luteinizing Hormone Secretion
• Sex Differentiation
• Cell Growth

PTMs

• Phosphorylation
• Cleavage
• Amidation

• Demethylation
• Glycosylation
• Methylation

• Acylation

Research Areas

• GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Kiss1r

Best Uses Of The KISS1R Marker By Boster Bio

In this article, I'll explain the history of Steven Boster, who developed the KISS1R marker and the advantages of using the new Anti-KISS1 receptor/KISS1R antibody Picoband(tm) by Boster Bio. I'll also discuss the best uses of the KISS1R marker. This article is applicable to all scientists around the world.

Boster Bio Anti-KISS1 receptor antibody/KISS1R picoband(tm);

Boster Bio's antibody comes as a purified, polyclonal antibody. It is available in PBS that contains 0.09 percent sodium azide. The antibody was isolated from rabbits that had been immunized with an artificial protein that corresponds to 20 to 52 amino acids in human KISS1. You can buy a blocking peptide that has the same length.

The antibody reacts with both mouse and human KISS1 receptor. The antibody contains five milligrams BSA. It recognizes human NR3C2's C-terminus, a subunit from the KISS1 receptor. The antibody binds to this molecule in cells and is a highly effective tool for immunohistochemistry.

Best uses of KISS1R Marker

The KISS1R Marker can be used to analyze the effects of Arg386Pro mutation on KISS1R degradation. The protein is destroyed by the proteasome system. This marker is used in a variety of research areas. It can be used to help researchers discover the mechanisms which lead to the degradation of KISS1R. This marker isn't just useful for diagnosing KISS1R, it can also be utilized to perform a variety biological tasks.