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- Table of Contents
Facts about KiSS-1 receptor.
Receptor for metastin, a C-terminally amidated peptide of KiSS1.
KiSS1 is a metastasis suppressor protein.Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin-released hormone structure and for puberty.
Rat | |
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Gene Name: | Kiss1r |
Uniprot: | Q924U1 |
Entrez: | 78976 |
Belongs to: |
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G-protein coupled receptor 1 family |
AXOR12; AXOR12hypogonadotropin-1; G protein-coupled receptor 54; GPR54; GPR54kiSS-1R; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; HOT7T175; Hypogonadotropin-1; KISS1 receptor; kiSS-1 receptor; KiSS1R; KiSS-1R; Kisspeptins receptor; Metastin Receptor; OT7T175
Mass (kDA):
42.889 kDA
Rat | |
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Location: | 7q11 |
Sequence: | 7; |
Highest expression levels in the cerebrum and cecum. Moderate expression in the ovary, colon and placenta. Low levels in the uterus, small intestine, and thymus. Expressed only moderately in the placenta. No expression in kidney tissues. Has a complex and abundant central nervous system expression pattern. Expressed in brain regions such as pons, midbrain, thalamus, hypothalamus, hippocampus, amygdala, cortex, frontal cortex, and striatum. No expression in the cerebellum. Persistent expression is detected in hypothalamus throughout postnatal development, with maximum expression levels at puberty in both male and female. Hypothalamic expression changed throughout the estrus cycle and is significantly increased after gonadectomy, a rise that is prevented by sex steroid replacement both in males and females.
PMID: 10100623 by Lee D.K., et al. Discovery of a receptor related to the galanin receptors.
PMID: 11385580 by Ohtaki T., et al. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G- protein-coupled receptor.