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- Table of Contents
Facts about Metastasis-suppressor KiSS-1.
Generates a C-terminally amidated peptide, metastin which acts as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell regeneration, key features of tumor metastasis.
Human | |
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Gene Name: | KISS1 |
Uniprot: | Q15726 |
Entrez: | 3814 |
Belongs to: |
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KISS1 family |
KiSS-1 metastasis-suppressor; KiSS1; KiSS-1; kisspeptin; Kisspeptin-1; malignant melanoma metastasis-suppressor; metastasis-suppressor KiSS-1; Metastin; MGC39258
Mass (kDA):
14.705 kDA
Human | |
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Location: | 1q32.1 |
Sequence: | 1; NC_000001.11 (204190341..204196491, complement) |
Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
Secreted.
PMID: 8944003 by Lee J.-H., et al. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene.
PMID: 9806840 by West A., et al. Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).