Metastasis-suppressor KiSS-1 (KISS1)

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization.

Generates a C-terminally amidated peptide, metastin which acts as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell regeneration, key features of tumor metastasis.