KIF5A Antibodies

AND KIF5A ELISA kits, KIF5A Proteins

Many biological assays use antibodies to detect KIF5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIF5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIF5A antibodies...

We validate the specificity of these antibodies to KIF5A by testing them on tissues known to express KIF5A positively and negatively. Browse below to find the KIF5A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KIF5A Infographic by Boster Bio

All KIF5A Products

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Product

Figures

Specificity

Applications

Price

Anti-KIF5 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$449
Cat # A03635
0.1 mg

Anti-KIF5A Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03635-1
100 μg/vial

Kinesin 5A (KIF5A) (NM_004984) Human Over-expression Lysate

Human

$960
Cat # LS003798
100 µg

KIF5A Overview

Facts about Kinesin heavy chain isoform 5A.

KIF5A 3D structure. Source: alphafold

Kinesin heavy chain isoform 5A (KIF5A)

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells at a ZFYVE27-dependent manner.

The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 that's vital for MAPK8IP3/JIP3 function in axon elongation.

Gene Information

Human
Gene Name:	KIF5A
Uniprot:	Q12840
Entrez:	3798

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

D12S1889; KIF5A variant protein; kinesin family member 5A; kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; kinesin, heavy chain, neuron-specific; MY050; Neuronal kinesin heavy chain; NKHC1; NKHCspastic paraplegia 10 (autosomal dominant); SPG10

Molecular Weight

Mass (kDA):
117.378 kDA

Genomic Context


Human

Location:	12q13.3
Sequence:	12; NC_000012.12 (57550039..57586633)

Tissue Specificity

Distributed throughout the CNS but is highly enriched in subsets of neurons.

Subcellular Localizations

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Perikaryon. Concentrated in the cell body of the neurons, particularly in the perinuclear region.

Diseases

Paraplegia
Spastic Paraplegia
Spastic Paraplegia, Hereditary
Rheumatoid Arthritis
Arthritis
Neurodegenerative Disorders
Nervousness
Autoimmune Diseases
Autoimmune Reaction
Sclerosis
Weakness
Muscle Spasticity

Malignant Neoplasms
Lupus Erythematosus, Systemic
Diabetes Mellitus
Peripheral Neuropathy
Diabetes Mellitus, Insulin-dependent
Multiple Sclerosis

Interacting Proteins

ANKRD27
Trak2

Pathways

Transport
Localization
Pathogenesis
Intracellular Transport
Mrna Transport
Cell Division
Rna Interference
Synaptic Transmission
Intracellular Signal Transduction
Membrane Fusion
Neuron Death
Energy Homeostasis
Cytokinesis

Mitochondrial Transport
Translation
Regulation Of Translation
Rna Processing
Nucleocytoplasmic Transport
Exocytosis
Meiosis

PTMs

Phosphorylation

Research Areas

Cell Biology
Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIF5A

References

PMID: 7514426 by Niclas J., et al. Cloning and localization of a conventional kinesin motor expressed exclusively in neurons.

PMID: 20386726 by Splinter D., et al. Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.