Kinesin-1 heavy chain Antibodies

AND KIF5B ELISA kits, Kinesin-1 heavy chain Proteins

Many biological assays use antibodies to detect Kinesin-1 heavy chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kinesin-1 heavy chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kinesin-1 heavy chain antibodies...

We validate the specificity of these antibodies to Kinesin-1 heavy chain by testing them on tissues known to express KIF5B positively and negatively. Browse below to find the KIF5B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KIF5B Infographic by Boster Bio

All KIF5B Products

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Anti-Kinesin-1 heavy chain KIF5B Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A01934
100ul

Anti-KIF5B Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M01934
100 μl/vial

KIF5B Overview

Facts about Kinesin-1 heavy chain.

KIF5B 3D structure. Source: alphafold

Kinesin-1 heavy chain (KIF5B)

Microtubule-dependent motor needed for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells at a ZFYVE27-dependent way (By similarity).

Regulates centrosome and nuclear positioning during mitotic entry. During the G2 stage of the cell cycle at a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726).

Gene Information

Human
Gene Name:	KIF5B
Uniprot:	P33176
Entrez:	3799

Family

Belongs to:

TRAFAC class myosin-kinesin ATPase superfamily

Alternative Names

Conventional kinesin heavy chain; kinesin family member 5B; kinesin-1 heavy chain; KNS1kinesin 1 (110-120kD); KNSKINH; Ubiquitous kinesin heavy chain; UKHCkinesin heavy chain

Molecular Weight

Mass (kDA):
109.685 kDA

Genomic Context


Human

Location:	10p11.22
Sequence:	10; NC_000010.11 (32009015..32056425, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Uniformly distributed between soma and neurites in hippocampal neurons.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Lung
Lung Neoplasms
Adenocarcinoma
Non-small Cell Lung Carcinoma
Neoplasms
Adenocarcinoma Of Lung (disorder)
Lymphoma
Anaplastic Lymphoma
Carcinoma
Cell Transformation, Neoplastic
Nervousness
Cell Invasion

Salmonella Infections
Abnormal Degeneration
Vaccinia
Bronchioloalveolar Adenocarcinoma
Tissue Adhesions
Sclerosis
Neoplasm Metastasis

Interacting Proteins

FYCO1
Syne4
YWHAZ

Pathways

Transport
Localization
Secretion
Synaptic Transmission
Exocytosis
Pathogenesis
Intracellular Transport
Insulin Secretion
Cell Migration
Membrane Fusion
Protein Transport
Neurogenesis
Translation

Meiosis
Endocytosis
Autophagy
Cell Adhesion
Diapedesis
Nuclear Export
Embryo Development

PTMs

Phosphorylation
Cleavage

Acetylation
Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIF5B

References

PMID: 1607388 by Navone F., et al. Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells.

PMID: 15459722 by Su Q., et al. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.