Kinesin-like protein KIF14 (KIF14)

Microtubule motor protein which binds to microtubules with high affinity through every tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in several processes like cell division, cytokinesis and in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480).

During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). During cell cycle progression behaves through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, leading to positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087).