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- Table of Contents
Facts about Kinesin-like protein KIF14.
During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). During cell cycle progression behaves through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, leading to positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087).
Human | |
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Gene Name: | KIF14 |
Uniprot: | Q15058 |
Entrez: | 9928 |
Belongs to: |
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TRAFAC class myosin-kinesin ATPase superfamily |
KIAA0042MGC142302; kinesin family member 14; kinesin-like protein KIF14
Mass (kDA):
186.492 kDA
Human | |
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Location: | 1q32.1 |
Sequence: | 1; NC_000001.11 (200551497..200620791, complement) |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Midbody. Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission,
PMID: 15843429 by Zhu C., et al. Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.
PMID: 16431929 by Gruneberg U., et al. KIF14 and citron kinase act together to promote efficient cytokinesis.