KIAA0319 Antibodies

AND KIAA0319 ELISA kits, KIAA0319 Proteins

Many biological assays use antibodies to detect KIAA0319, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KIAA0319 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KIAA0319 antibodies...

We validate the specificity of these antibodies to KIAA0319 by testing them on tissues known to express KIAA0319 positively and negatively. Browse below to find the KIAA0319 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KIAA0319 Infographic by Boster Bio

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KIAA0319 Overview

Facts about Dyslexia-associated protein KIAA0319.

KIAA0319 3D structure. Source: alphafold

Dyslexia-associated protein KIAA0319 (KIAA0319)

Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a part in proper adhesion between migrating neurons and radial glial fibers.

May also regulate growth and differentiation of dendrites. .

Gene Information

Human
Gene Name:	KIAA0319
Uniprot:	Q5VV43
Entrez:	9856

Family

Belongs to:

No superfamily

Alternative Names

4930451E12Rik; D130043K22; DLX2; DYLX2; dyslexia susceptibility 2; DYX2; KIAA0319; MGC176717; NMIG

Molecular Weight

Mass (kDA):
117.763 kDA

Genomic Context


Human

Location:	6p22.3
Sequence:	6; NC_000006.12 (24540128..24646191, complement)

Tissue Specificity

Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted.

Diseases

Dyslexia
Developmental Reading Disorder
Impairment (finding)
Learning Disorders
Language Disorders
Specific Language Impairment
Dysequilibrium Syndrome
Learning Disabilities
Attention Deficit Hyperactivity Disorder
Ectopic Tissue
Apraxias
Language Development Disorders
Schizophrenia

Developmental Disabilities
Succinate-semialdehyde Dehydrogenase Deficiency
Malnutrition
Fracture Of First Cervical Vertebra
Dysplasia
Inattention
Steroid Sulfatase Deficiency Disease

Pathways

Brain Development
Cognition
Rna Interference
Endocytosis
Localization
Clathrin-mediated Endocytosis
Short-term Memory
Axon Guidance

Cell Motility
Prepulse Inhibition
Regulation Of Gene Expression

PTMs

Glycosylation

Cleavage

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KIAA0319

References

PMID: 12834540 by Londin E.R., et al. A transcription map of the 6p22.3 reading disability locus identifying candidate genes.

PMID: 16600991 by Paracchini S., et al. The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration.