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- Table of Contents
Facts about Centrosome-associated protein 350.
Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA action (PubMed:15615782). Required for ciliation (PubMed:28659385).
Human | |
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Gene Name: | CEP350 |
Uniprot: | Q5VT06 |
Entrez: | 9857 |
Belongs to: |
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No superfamily |
CAP350GM133; centrosomal protein 350kDa; centrosome-associated protein 350; Centrosome-associated protein of 350 kDa; Cep350; FLJ38282; FLJ44058; KIAA0480centrosome associated protein 350
Mass (kDA):
350.93 kDA
Human | |
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Location: | 1q25.2 |
Sequence: | 1; NC_000001.11 (179954773..180114875) |
Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Associated with mitotic spindles (PubMed:16314388). Nuclear, in discrete foci. Associated with intermediate filaments (PubMed:15615782). Also present in the pericentrosomal area (PubMed:17878239). Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole
PMID: 11891061 by Makalowska I., et al. Identification of six novel genes by experimental validation of GeneMachine predicted genes.
PMID: 15615782 by Patel H., et al. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome- associated protein CAP350.