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Khdrbs2 Antibodies
AND Khdrbs2 ELISA kits, Khdrbs2 Proteins
Many biological assays use antibodies to detect Khdrbs2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Khdrbs2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Khdrbs2 antibodies...
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Khdrbs2 Overview
Facts about KH domain-containing, RNA-binding, signal transduction-associated protein 2.
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Khdrbs2)
RNA-binding protein which plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon addition (By similarity). Binds both poly(A) and poly(U) homopolymers.
Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Khdrbs2 |
| Uniprot: | Q9WU01 |
| Entrez: | 170771 |
Family
| Belongs to: |
|---|
| KHDRBS family |
Alternative Names
hSLM-1; KH domain containing, RNA binding, signal transduction associated 2; KH domain-containing, RNA-binding, signal transduction-associated protein 2; MGC26664; Sam68-like mammalian protein 1; SLM1bA535F17.1; SLM-1FLJ38664
Molecular Weight
Mass (kDA):
38.866 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1|1 B |
| Sequence: | 1; |
Tissue Specificity
Expressed in heart, skin, brain, colon, spleen, kidney, cervix and testis. In adult cerebellum expressed predominantly in Purkinje cells and in the hippocampus is abundantly expressed in glutamatergic dentate granule cells and in specific inhibitory Schaffer collateral-associated and path- associated interneurons; expression is restricted to neuronal subpopulations largely non-overlapping with expression of KHDRBS3/SLM-2 (at protein level).
Diseases
- Malignant Neoplasms
- Hiv Infections
- Immunologic Deficiency Syndromes
- Neoplasms
- Adenocarcinoma
- Lung Neoplasms
- Retinal Degeneration
- Kidney Neoplasm
- Retinitis Pigmentosa
- Malignant Neoplasm Of Lung
- Carcinogenesis
Pathways
- Transport
- Translation
- Mitosis
- Localization
- Methylation
- Mrna Transcription
- Dna Hypermethylation
- Dna Hypomethylation
- Fertilization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Khdrbs2
bosterbio.com/bosterbio-gene-info-cards/Khdrbs2
References
PMID: 10077576 by Di Fruscio M., et al. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
PMID: 15471878 by Haegebarth A., et al. The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.