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- Table of Contents
Facts about KH domain-containing, RNA-binding, signal transduction-associated protein 1.
Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also functions as a putative regulator of mRNA stability and/or translation speeds and mediates mRNA nuclear export.
Human | |
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Gene Name: | KHDRBS1 |
Uniprot: | Q07666 |
Entrez: | 10657 |
Belongs to: |
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KHDRBS family |
FLJ34027; GAP-associated tyrosine phosphoprotein p62; KH domain containing, RNA binding, signal transduction associated 1; KH domain-containing, RNA-binding, signal transduction-associated protein 1; KHDRBS1; p21 Ras GTPase-activating protein-associated p62; p62; p68; SAM68; Sam68GAP-associated tyrosine phosphoprotein p62 (Sam68); Src-associated in mitosis 68 kDa protein
Mass (kDA):
48.227 kDA
Human | |
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Location: | 1p35.2 |
Sequence: | 1; NC_000001.11 (32013868..32060850) |
Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
Nucleus. Cytoplasm. Membrane. Predominantly located in the nucleus but also located partially in the cytoplasm.
PMID: 1374686 by Wong G., et al. Molecular cloning and nucleic acid binding properties of the GAP- associated tyrosine phosphoprotein p62.
PMID: 9013542 by Barlat I., et al. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain.