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- Table of Contents
Facts about CUGBP Elav-like family member 1.
Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition.
Human | |
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Gene Name: | CELF1 |
Uniprot: | Q92879 |
Entrez: | 10658 |
Belongs to: |
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CELF/BRUNOL family |
BRUNOL2; BRUNOL250 kDa nuclear polyadenylated RNA-binding protein; bruno-like 2; Bruno-like protein 2; CELF1; CUG RNA-binding protein; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUGBP Elav-like family member 1; CUG-BP; CUGBP, Elav-like family member 1; CUGBP1; CUG-BP1; CUGBP1CUG triplet repeat RNA-binding protein 1; CUGBPCELF-1; D2Wsu101e; Deadenylation factor CUG-BP; EDEN-BP homolog; EDEN-BP; embryo deadenylation element binding protein; Embryo deadenylation element-binding protein homolog; HNAB50; NAB50; NAB50CUG-BP1
Mass (kDA):
52.063 kDA
Human | |
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Location: | 11p11.2 |
Sequence: | 11; NC_000011.10 (47465937..47565539, complement) |
Ubiquitous.
Nucleus. Cytoplasm. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
PMID: 8948631 by Timchenko L.T., et al. Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
PMID: 10893231 by Good P.J., et al. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.