KEAP1 Antibodies

AND KEAP1 ELISA kits, KEAP1 Proteins

Many biological assays use antibodies to detect KEAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KEAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KEAP1 antibodies...

We validate the specificity of these antibodies to KEAP1 by testing them on tissues known to express KEAP1 positively and negatively. Browse below to find the KEAP1 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KEAP1 Infographic by Boster Bio

All KEAP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Keap1 Antibody Picoband®

3 Citations 16 Q&As

Human

$370
Cat # PB9762
100 μg/vial

Anti-KEAP1 Antibody

1 Citations

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A00514
0.1 mg

Anti-Keap1 Antibody

2 Citations

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A00514-2
100ul

KEAP1 (NM_012289) Human Recombinant Protein

$1249
Cat # PROTQ14145
20 µg

Anti-KEAP1 Mouse Monoclonal Antibody [Clone ID: OTI1B4]

+12

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M00514
100 µl

Anti-KEAP1 Antibody Picoband®

3 Citations

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00514-3
100 μg/vial

KEAP1 (NM_203500) Human Over-expression Lysate

Human

$628
Cat # LS009817
100 µg

KEAP1 Overview

Facts about Kelch-like ECH-associated protein 1.

KEAP1 3D structure. Source: alphafold

Kelch-like ECH-associated protein 1 (KEAP1)

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus leading to the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol.

Targets PGAM5 for ubiquitination and degradation by the proteasome. .

Gene Information

Human
Gene Name:	KEAP1
Uniprot:	Q14145
Entrez:	9817

Family

Belongs to:

KEAP1 family

Alternative Names

INrf2; INrf2MGC9454; Keap1; kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132MGC4407; KLHL19Cytosolic inhibitor of Nrf2; MGC10630; MGC1114; MGC20887

Molecular Weight

Mass (kDA):
69.666 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (10486125..10503356, complement)

Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle.

Subcellular Localizations

Cytoplasm. Nucleus. Mainly cytoplasmic (PubMed:15601839). In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62 (PubMed:20452972).

Diseases

Malignant Neoplasms
Neoplasms
Carcinogenesis
Inflammation
Carcinoma
Neurodegenerative Disorders
Malignant Neoplasm Of Lung
Cell Transformation, Neoplastic
Lung Neoplasms
Liver Carcinoma
Non-small Cell Lung Carcinoma
Adenocarcinoma
Parkinson Disease

Nerve Degeneration
Liver Neoplasms
Cardiovascular Diseases
Malignant Neoplasm Of Breast
Atherosclerosis
Mammary Neoplasms
Abnormal Degeneration

Interacting Proteins

AMER1
ASPA
CCNB1IP1
DPP3
ETF1

FAM117B
IKBKB
Ikbkb
Irf1
LSM3

MAD2L1
MAPKBP1
NFE2L2
NUDT4
PALB2

PRKAG1
RELA
SESN2
SQSTM1
Sqstm1

TERF1
TSC22D4
WDR83
ZSCAN32

Pathways

Localization
Cell Death
Pathogenesis
Response To Oxidative Stress
Neuroprotection
Cell Proliferation
Conjugation
Autophagy
Drug Resistance
Aging
Cell Cycle
Nuclear Export
Sensitization

Cell Cycle Arrest
Rna Interference
Translation
Nuclear Import
Cell Growth
Angiogenesis
Defense Response

PTMs

Ubiquitination
Phosphorylation
Oxidation
Reduction
Methylation
Nitrosylation

Cleavage
Biotinylation
Acetylation
Glutathionylation
Demethylation
Nitration

Deacetylation

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KEAP1

References

PMID: 14585973 by Zhang D.D., et al. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.

PMID: 15379550 by Strachan G.D., et al. Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

7 Publications of Boster KEAP1 Antibodies & ELISA Kits

PubMed ID: 10.1039/C6RA14831J, Individual and combined antioxidant effects of ginsenoside F2 and cyanidin-3-O-g...
PubMed ID: 10.1016/j.carbpol.2018.01.075, Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress da...
PubMed ID: 10.1002/jcp.26769, Andrographolide protects chondrocytes from oxidative stress injury by activation...
PubMed ID: 33359640, Li D,Bai X,Jiang Y,Cheng Y.Butyrate alleviates PTZ-induced mitochondrial dysfunc...
PubMed ID: 26339340, Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary f...
PubMed ID: 29744366, Zhu X, Chen Y, Chen Q, Yang H, Xie X. J Diabetes Res. 2018 Mar 21;2018:6730315. ...
PubMed ID: 25288107, Deng Y, Zhu J, Mi C, Xu B, Jiao C, Li Y, Xu D, Liu W, Xu Z. Neurotox Res. 2015 F...

*More publications can be found for each product on its corresponding product page