Cullin-7 Antibodies

AND CUL7 ELISA kits, Cullin-7 Proteins

Many biological assays use antibodies to detect Cullin-7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cullin-7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cullin-7 antibodies...

We validate the specificity of these antibodies to Cullin-7 by testing them on tissues known to express CUL7 positively and negatively. Browse below to find the CUL7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CUL7 Infographic by Boster Bio

All CUL7 Products

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Product

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Specificity

Applications

Price

Anti-Cul7/Cullin 7 Antibody

4 Q&As

Human

IP, IHC, WB

$629
Cat # A03179
100uL

Anti-Cullin-7 CUL7 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A03179-1
100ul

CUL7 Overview

Facts about Cullin-7.

CUL7 3D structure. Source: alphafold

Cullin-7 (CUL7)

Core part of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695).

Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026).

Gene Information

Human
Gene Name:	CUL7
Uniprot:	Q14999
Entrez:	9820

Family

Belongs to:

cullin family

Alternative Names

CUL-7; cullin 7; cullin-7; KIAA0076dJ20C7.5

Molecular Weight

Mass (kDA):
191.161 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (43037617..43053945, complement)

Tissue Specificity

Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Colocalizes with FBXW8 at the Golgi apparatus in neurons; localization to Golgi is mediated by OBSL1. During mitosis, localizes to the mitotic apparatus (PubMed:24793695). CCDC8 is required for centrosomal location (PubMed:24793695).