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- Table of Contents
Facts about Lysine-specific demethylase 6A.
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).
Human | |
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Gene Name: | KDM6A |
Uniprot: | O15550 |
Entrez: | 7403 |
Belongs to: |
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UTX family |
bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeatprotein (UTX)); bA386N14.2; DKFZp686A03225; EC 1.14.11; EC 1.14.11.-; Histone demethylase UTX; KABUK2; KDM6A; Lysine (K)specific Demethylase 6A; Lysine (K)-specific Demethylase 6A; MGC141941; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously transcribed tetratricopeptide repeat, X chromosome; ubiquitously transcribed TPR protein on the X chromosome; ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; Ubiquitously-tra
Mass (kDA):
154.177 kDA
Human | |
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Location: | Xp11.3 |
Sequence: | X; NC_000023.11 (44873175..45112779) |
Nucleus.
PMID: 9381176 by Lahn B.T., et al. Functional coherence of the human Y chromosome.
PMID: 17500065 by Cho Y.-W., et al. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.