This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Lysine-specific demethylase 4B.
Only able to demethylate trimethylated H3'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Human | |
---|---|
Gene Name: | KDM4B |
Uniprot: | O94953 |
Entrez: | 23030 |
Belongs to: |
---|
JHDM3 histone demethylase family |
EC 1.14.11; FLJ44906; JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2BEC 1.14.11.-; jumonji domain containing 2B; Jumonji domain-containing protein 2B; KIAA0876lysine-specific demethylase 4B; lysine (K)-specific demethylase 4B
Mass (kDA):
121.897 kDA
Human | |
---|---|
Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (4969087..5153603) |
Nucleus.
PMID: 15927959 by Gray S.G., et al. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein.
PMID: 16603238 by Whetstine J.R., et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.