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- Table of Contents
Facts about Lysine-specific histone demethylase 1B.
Acts by oxidizing the substrate by FAD to create the corresponding imine that's subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Mouse | |
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Gene Name: | Kdm1b |
Uniprot: | Q8CIG3 |
Entrez: | 218214 |
Belongs to: |
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flavin monoamine oxidase family |
AOF1; bA204B7.3; C6orf193; dJ298J15.2; DKFZp686I0412; flavin containing 1; flavin-containing amine oxidase domain-containing protein 1; FLJ33898; FLJ34109; FLJ43328; LSD2; lysine (K)-specific demethylase 1B; lysine-specific histone demethylase 1B; lysine-specific histone demethylase 2
Mass (kDA):
92.633 kDA
Mouse | |
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Location: | 13|13 A5 |
Sequence: | 13; |
Expressed in growing oocytes and in intestinal gland.
PMID: 19407342 by Karytinos A., et al. A novel mammalian flavin-dependent histone demethylase.
PMID: 19727073 by Ciccone D.N., et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.