KCTD21 Antibodies

AND KCTD21 ELISA kits, KCTD21 Proteins

Many biological assays use antibodies to detect KCTD21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCTD21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCTD21 antibodies...

We validate the specificity of these antibodies to KCTD21 by testing them on tissues known to express KCTD21 positively and negatively. Browse below to find the KCTD21 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCTD21 Infographic by Boster Bio

All KCTD21 Products

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Product

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Specificity

Applications

Price

KCTD21 (NM_001029859) Human Recombinant Protein

$813
Cat # PROTQ4G0X4
20 µg

KCTD21 (NM_001029859) Human Over-expression Lysate

Human

$628
Cat # LS283219
100 µg

KCTD21 Overview

Facts about BTB/POZ domain-containing protein KCTD21.

KCTD21 3D structure. Source: alphafold

BTB/POZ domain-containing protein KCTD21 (KCTD21)

Probable substrate-specific adapter of a BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1.

Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function likely occurs via HDAC1 down-regulation, maintaining GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142).

Gene Information

Human
Gene Name:	KCTD21
Uniprot:	Q4G0X4
Entrez:	283219

Family

Belongs to:

No superfamily

Alternative Names

BTB/POZ domain-containing protein KCTD21; KCASH2; potassium channel tetramerisation domain containing 21

Molecular Weight

Mass (kDA):
29.643 kDA

Genomic Context


Human

Location:	11q14.1
Sequence:	11; NC_000011.10 (78171243..78188626, complement)

Diseases

Cell Transformation, Neoplastic
Cerebellar Neoplasms
Neoplasms
Malignant Neoplasm Of Brain
Malignant Paraganglionic Neoplasm
Medulloblastoma

Brain Neoplasms

PTMs

Deacetylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCTD21

References

PMID: 21472142 by De Smaele E., et al. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.